LncRNAs and cancer

被引：99

作者：

Zhang, Rui ^{[1
]}

Xia, Li Qiong ^{[1
]}

Lu, Wen Wen ^{[1
]}

Zhang, Jing ^{[1
]}

Zhu, Jin-Shui ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 6, Dept Gastroenterol, 600 Yishan Rd, Shanghai 200233, Peoples R China

来源：

ONCOLOGY LETTERS | 2016年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; HOTAIR; MALAT1; cancer; LONG NONCODING RNA; CELL LUNG-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; POOR-PROGNOSIS; PROSTATE-CANCER; GASTRIC-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; BREAST-CANCER; STEM-CELLS;

D O I：

10.3892/ol.2016.4770

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs composed of >200 nucleotides. Recent studies have revealed that lncRNAs exert an important role in the development and progression of cancer. In this review, the involvement of the most extensively investigated lncRNAs in cancers of the digestive, respiratory, reproductive, urinary and central nervous systems are discussed. LncRNAs function via molecular and biochemical mechanisms that include cis- and trans-regulation of gene expression, epigenetic modulation in the nucleus and post-transcriptional control in the cytoplasm. Although the detailed biological functions and molecular mechanisms of the majority of lncRNAs remain to be elucidated, this review aims to provide a novel insight into the diagnosis and treatment of cancer using lncRNAs.

引用

页码：1233 / 1239

页数：7

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