Pd(II)-catalyzed oxidative cyclization reaction for the preparation of 2-substituted 1,2,3,4-tetrahydroquinolines with halide functionality

被引：17

作者：

Jiang, Feng ^{[1
]}

Wu, Zhengxing ^{[1
]}

Zhang, Wanbin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

来源：

TETRAHEDRON | 2011年 / 67卷 / 07期

关键词：

Oxidative cyclization reaction; Pd(II); 2-Substituted 1,2,3,4-tetrahydroquinolines; Olefinic tosylamides; Halide functionality; WACKER-TYPE CYCLIZATION; ASSISTED INTRAMOLECULAR AMINATION; NITROGEN-HETEROCYCLES; TETRAOXAZOLINE LIGANDS; BISOXAZOLINE LIGANDS; OLEFINIC TOSYLAMIDES; QUINOLINES; INHIBITORS; BIPHENYL; AGENTS;

D O I：

10.1016/j.tet.2010.12.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first Pd(II)-catalyzed oxidative cyclization reaction was developed for preparation of 2-substituted 1,2,3,4-tetrahydroquinolines from olefinic tosylamides. Under the optimized conditions, up to 86% yield was obtained. This reaction provides direct and easy access to 2-substituted 1,2,3,4-tetrahydroquinolines with halide functionality. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1501 / 1505

页数：5

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