Vif Proteins of Human and Simian Immunodeficiency Viruses Require Cellular CBFβ To Degrade APOBEC3 Restriction Factors

被引：62

作者：

Hultquist, Judd F. ^{[1
,2
]}

Binka, Mawuena ^{[3
]}

LaRue, Rebecca S. ^{[1
]}

Simon, Viviana ^{[3
,4
,5
]}

Harris, Reuben S. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Inst Mol Virol, Ctr Genome Engn,Masonic Canc Ctr, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Mol Cellular Dev Biol & Genet, Minneapolis, MN USA

[3] Mt Sinai Sch Med, Dept Microbiol, New York, NY USA

[4] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY USA

[5] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 05期

关键词：

HIV-1; UBIQUITINATION; COMPLEX;

D O I：

10.1128/JVI.06950-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 requires the cellular transcription factor CBF beta to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBF beta allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins from multiple HIV-1 subtypes and is required for the degradation of all human and rhesus Vif-sensitive APOBEC3 proteins by their respective lentiviral Vif proteins.

引用

页码：2874 / 2877

页数：4

共 13 条

[11] Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins
Virgen, Cesar A.
Hatziioannou, Theodora
[J]. JOURNAL OF VIROLOGY, 2007, 81 (24) : 13932 - 13937
[12] Host Restriction Factors Blocking Retroviral Replication
Wolf, Daniel
Goff, Stephen P.
[J]. ANNUAL REVIEW OF GENETICS, 2008, 42 : 143 - 163
[13] Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex
Yu, XH
Yu, YK
Liu, BD
Luo, K
Kong, W
Mao, PY
Yu, XF
[J]. SCIENCE, 2003, 302 (5647) : 1056 - 1060

← 1 2 →