Ric-8: Different cellular roles for a heterotrimeric G-protein GEF

被引：25

作者：

Hinrichs, M. V. ^{[1
]}

Torrejon, M. ^{[1
]}

Montecino, M. ^{[2
,3
,4
]}

Olate, J. ^{[1
]}

机构：

[1] Univ Concepcion, Dept Biochem & Mol Biol, Fac Biol Sci, Concepcion, Chile

[2] Univ Andres Bello, Fac Med, Santiago, Chile

[3] Univ Andres Bello, Fac Biol Sci, Ctr Biomed Res, Santiago, Chile

[4] Univ Andres Bello, FONDAP Ctr Genome Regulat, Santiago, Chile

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2012年 / 113卷 / 09期

关键词：

Ric-8; GEF; G-PROTEIN; SIGNAL TRANSDUCTION; NUCLEOTIDE EXCHANGE FACTOR; ASYMMETRIC DIVISION; SIGNAL-TRANSDUCTION; ALPHA-SUBUNITS; EXPRESSION; DROSOPHILA; SYNEMBRYN; GROWTH; NUMA; GENE;

D O I：

10.1002/jcb.24162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signaling via heterotrimeric G-proteins is evoked by agonist-mediated stimulation of seven transmembrane spanning receptors (GPCRs). During the last decade it has become apparent that Ga subunits can be activated by receptor-independent mechanisms. Ric-8 belongs to a highly conserved protein family that regulates heterotrimeric G-protein function, acting as a non-canonical guanine nucleotide exchange factors (GEF) over a subset of Ga subunits. In this review we discuss the roles of Ric-8 in the regulation of diverse cell functions, emphasizing the contribution of its multiple domain protein structure in these diverse functions. J. Cell. Biochem. 113: 27972805, 2012. (C) 2012 Wiley Periodicals, Inc.

引用

页码：2797 / 2805

页数：9

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