OASL - a new player in controlling antiviral innate immunity

被引：81
|
作者：
Zhu, Jianzhong [1 ,2 ]
Ghosh, Arundhati [1 ,2 ]
Sarkar, Saumendra N. [1 ,2 ]
机构：
[1] Univ Pittsburgh, Inst Canc, Canc Virol Program, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA
来源：
CURRENT OPINION IN VIROLOGY | 2015年 / 12卷
关键词：
SINGLE NUCLEOTIDE POLYMORPHISMS; UBIQUITIN-LIKE DOMAIN; CYTOSOLIC DNA SENSOR; INFLUENZA-A VIRUS; RIG-I PATHWAY; 2'-5'-OLIGOADENYLATE SYNTHETASE; STRANDED-RNA; NS1; PROTEIN; HEPATITIS-C; INTERFERON;
D O I：
10.1016/j.coviro.2015.01.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.
引用
收藏
页码：15 / 19
页数：5
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