Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats

被引：39

作者：

Han, Xiao ^{[1
]}

Li, Nanxin ^{[1
,2
]}

Xue, Xiaofang ^{[1
]}

Shao, Feng ^{[1
]}

Wang, Weiwen ^{[3
]}

机构：

[1] Peking Univ, Dept Psychol, Beijing 100871, Peoples R China

[2] Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA

[3] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China

来源：

BRAIN RESEARCH | 2012年 / 1447卷

关键词：

Adolescence; Social isolation; Latent inhibition; Dopamine D2 receptor; Medial prefrontal cortex; Nucleus accumbens; PREPULSE INHIBITION; STRESS; BEHAVIOR; ADOLESCENCE; RESPONSES; MODEL; SCHIZOPHRENIA; PHARMACOLOGY; PERFORMANCE; MEMORY;

D O I：

10.1016/j.brainres.2012.01.058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of pen-adolescent social isolation on latent inhibition (LI) and dopamine 02 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：38 / 43

页数：6

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