Phantom Model of Physiologic Intracranial Pressure and Cerebrospinal Fluid Dynamics

被引:23
|
作者
Bottan, Simone [1 ]
Poulikakos, Dimos [1 ]
Kurtcuoglu, Vartan [1 ]
机构
[1] ETH, Lab Thermodynam Emerging Technol, Dept Mech & Proc Engn, CH-8092 Zurich, Switzerland
基金
瑞士国家科学基金会;
关键词
Anatomical model; compliance; subarachnoid space (SAS); ventricular system; SUBARACHNOID SPACE; FLOW; HYDROCEPHALUS; BLOOD; VALIDATION; AMPLITUDE; INFUSION;
D O I
10.1109/TBME.2012.2187448
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We describe herein a novel life-size phantom model of the intracranial cavity and its validation. The cerebrospinal fluid (CSF) domains including ventricular, cysternal, and subarachnoid spaces were derived via magnetic resonance imaging. Brain mechanical properties and cranio-spinal compliance were set based on published data. Both bulk and pulsatile physiologic CSF flow were modeled. Model validation was carried out by comparisons of flow and pressure measurements in the phantom with published in vivo data of healthy subjects. Physiologic intracranial pressure with 10 mmHg mean and 0.4 mmHg peak pulse amplitude was recorded in the ventricles. Peak CSF flow rates of 0.2 and 2 ml/s were measured in the cerebral aqueduct and subarachnoid space, respectively. The phantom constitutes a first-of-its-kind approach to modeling physiologic intracranial dynamics in vitro. Herein, we describe the phantom design and manufacturing, definition and implementation of its operating parameters, as well as the validation of the modeled dynamics.
引用
收藏
页码:1532 / 1538
页数:7
相关论文
共 50 条
  • [41] Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure
    Steffensen, Annette Buur
    Edelbo, Beatriche Louise
    Barbuskaite, Dagne
    Andreassen, Soren Norge
    Olsen, Markus Harboe
    Moller, Kirsten
    MacAulay, Nanna
    FLUIDS AND BARRIERS OF THE CNS, 2023, 20 (01)
  • [42] INTRACRANIAL CEREBROSPINAL-FLUID PRESSURE IN MAN DURING KETAMINE ANESTHESIA
    GARDNER, AE
    DEAN, D
    DANNEMILLER, FJ
    ANESTHESIA AND ANALGESIA CURRENT RESEARCHES, 1972, 51 (05): : 741 - +
  • [43] Retrolaminar cerebrospinal fluid pressure in compression of the intracranial optic nerves and chiasm
    Collison, Frederick T.
    ACTA OPHTHALMOLOGICA, 2011, 89 (05) : E476 - E477
  • [44] CEREBROSPINAL-FLUID PHYSIOLOGY AND THE MANAGEMENT OF INCREASED INTRACRANIAL-PRESSURE
    LYONS, MK
    MEYER, FB
    MAYO CLINIC PROCEEDINGS, 1990, 65 (05) : 684 - 707
  • [45] SIGNIFICANCE OF CEREBROSPINAL FLUID PRESSURE IN DETERMINING TIME FOR REPAIR OF INTRACRANIAL ANEURYSMS
    KLAFTA, LA
    HAMBY, WB
    JOURNAL OF NEUROSURGERY, 1969, 31 (02) : 217 - &
  • [46] CEREBROSPINAL-FLUID CIRCULATION, CEREBRAL EDEMA, AND INTRACRANIAL-PRESSURE
    WILLIAMS, MA
    RAZUMOVSKY, AY
    CURRENT OPINION IN NEUROLOGY, 1993, 6 (06) : 847 - 853
  • [47] How common is normal cerebrospinal fluid pressure in spontaneous intracranial hypotension?
    Kranz, Peter G.
    Tanpitukpongse, Teerath P.
    Choudhury, Kingshuk Roy
    Amrhein, Timothy J.
    Gray, Linda
    CEPHALALGIA, 2016, 36 (13) : 1209 - 1217
  • [48] Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure
    Annette Buur Steffensen
    Beatriche Louise Edelbo
    Dagne Barbuskaite
    Søren Norge Andreassen
    Markus Harboe Olsen
    Kirsten Møller
    Nanna MacAulay
    Fluids and Barriers of the CNS, 20
  • [49] The vascular factor in intracranial pressure and the maintenance of the cerebrospinal fluid circulation.
    O'Connell, JEA
    BRAIN, 1943, 66 : 204 - 228
  • [50] Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations: A phantom study
    Chu, D
    Levin, DN
    Alperin, N
    MAGNETIC RESONANCE IMAGING, 1998, 16 (09) : 1043 - 1048