Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model

被引:67
作者
Greenwald, Holly S. [1 ]
Friedman, Erica B. [1 ]
Osman, Iman [1 ]
机构
[1] NYU, Interdisciplinary Melanoma Cooperat Grp, Sch Med, New York, NY 10003 USA
关键词
histological subtype; linear progression; melanoma; nodular melanoma; superficial-spreading melanoma; COMPARATIVE GENOMIC HYBRIDIZATION; CUTANEOUS MALIGNANT-MELANOMA; GROWTH-FACTOR RECEPTOR; CELL LUNG-CANCER; N-RAS MUTATIONS; BRAF MUTATIONS; METASTATIC MELANOMA; MELANOCYTIC LESIONS; TUMOR PROGRESSION; GENE-EXPRESSION;
D O I
10.1097/CMR.0b013e32834e6aa0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The classification of melanoma subtypes into prognostically relevant and therapeutically insightful categories has been a challenge since the first description of melanoma in the 1800s. One limitation has been the assumption that the two most common histological subtypes of melanoma, superficial spreading and nodular, evolve according to a linear model of progression, as malignant melanocytes spread radially and then invade vertically. However, recent clinical, pathological, and molecular data indicate that these two histological subtypes might evolve as distinct entities. Here, we review the published data that support distinct molecular characterization of superficial spreading and nodular melanoma, the clinical significance of this distinction including prognostic relevance and the therapeutic implications. Melanoma Res 22: 1-8 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:1 / 8
页数:8
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