Heart rate variability in the prediction of survival in patients with cancer: A systematic review and meta-analysis

被引：99
作者：
Zhou, Xin [1 ]
Ma, Zhaolai [1 ]
Zhang, Lingfu [1 ]
Zhou, Shuzhe [2 ]
Wang, Jilian [1 ]
Wang, Bingyan [1 ]
Fu, Wei [1 ]
机构：
[1] Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
[2] Peking Univ, Natl Clin Res Ctr Mental Disorders, Key Lab Mental Hlth, Inst Mental Hlth,Minist Hlth,Hosp 6, Beijing 100191, Peoples R China
来源：
JOURNAL OF PSYCHOSOMATIC RESEARCH | 2016年 / 89卷
关键词：
Heart rate variability; Vagal nerve activity; Overall survival; Cancer; BREAST-CANCER; VAGUS NERVE; PROGNOSTIC VALUE; METASTASIS; MORTALITY; VAGOTOMY; OUTCOMES; THERAPY; PATHWAY; STRESS;
D O I：
10.1016/j.jpsychores.2016.08.004
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Purpose: Although the predictive value of vagal nerve activity, indexed by heart rate variability (HRV), has been confirmed in a variety of diseases, its value in the prediction of survival in cancer patients still remains controversial. The aim of this meta-analysis was to evaluate the predictive value of HRV in cancer patients in an evidence based manner. Methods: A systematic review and meta-analysis was conducted through a comprehensive search of the PubMed, EMBASE and the Cochrane Central Library databases for all studies regarding HRV, vagal nerve activity and cancer. Pooled data of overall survival was analyzed. Results: Six studies with 1286 patients were included in our meta analysis. Analysis of the pooled data revealed that overall survival was significantly longer in the higher HRV group than in the lower HRV group (HR 0.70, 95% CI [0.60, 0.82]; P < 0.001, 12 = 27%). Conclusion: The current evidence indicates a predictive value of HRV in the survival of patients with cancer and higher vagal nerve activity might predict longer survival, but the results should be applied with caution considering the heterogeneity between included studies. (C) 2016 Published by Elsevier Inc.
引用
收藏
页码：20 / 25
页数：6
相关论文
共 50 条
[1]  
[Anonymous], 2013, BIOMED RES INT, DOI DOI 10.1155/2013/503421
[2]  
[Anonymous], EUROPACE IN PRESS
[3]   Heart rate variability measure in breast cancer patients and survivors: A systematic review [J].
Arab, Claudia ;
Martins Dias, Daniel Penteado ;
de Almeida Barbosa, Renata Thais ;
de Carvalho, Tatiana Dias ;
Valenti, Vitor Engracia ;
Crocetta, Tania Brusque ;
Ferreira, Marcelo ;
de Abreu, Luiz Carlos ;
Ferreira, Celso .
PSYCHONEUROENDOCRINOLOGY, 2016, 68 :57-68
[4]   Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma [J].
Bald, Tobias ;
Quast, Thomas ;
Landsberg, Jennifer ;
Rogava, Meri ;
Glodde, Nicole ;
Lopez-Ramos, Dorys ;
Kohlmeyer, Judith ;
Riesenberg, Stefanie ;
van den Boorn-Konijnenberg, Debby ;
Hoemig-Hoelzel, Cornelia ;
Reuten, Raphael ;
Schadow, Benjamin ;
Weighardt, Heike ;
Wenzel, Daniela ;
Helfrich, Iris ;
Schadendorf, Dirk ;
Bloch, Wilhelm ;
Bianchi, Marco E. ;
Lugassy, Claire ;
Barnhill, Raymond L. ;
Koch, Manuel ;
Fleischmann, Bernd K. ;
Foerster, Irmgard ;
Kastenmueller, Wolfgang ;
Kolanus, Waldemar ;
Hoelzel, Michael ;
Gaffal, Evelyn ;
Tueting, Thomas .
NATURE, 2014, 507 (7490) :109-+
[5]   Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin [J].
Borovikova, LV ;
Ivanova, S ;
Zhang, MH ;
Yang, H ;
Botchkina, GI ;
Watkins, LR ;
Wang, HC ;
Abumrad, N ;
Eaton, JW ;
Tracey, KJ .
NATURE, 2000, 405 (6785) :458-462
[6]   Association Between Cardiovascular Autonomic Functions and Time to Death in Patients With Terminal Hepatocellular Carcinoma [J].
Chiang, Jui-Kun ;
Koo, Malcolm ;
Kuo, Terry B. J. ;
Fu, Chin-Hua .
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2010, 39 (04) :673-679
[7]   Sympathetic nervous system regulation of the tumour microenvironment [J].
Cole, Steven W. ;
Nagaraja, Archana S. ;
Lutgendorf, Susan K. ;
Green, Paige A. ;
Sood, Anil K. .
NATURE REVIEWS CANCER, 2015, 15 (09) :563-572
[8]   Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation [J].
De Couck, Marijke ;
Marechal, Raphael ;
Moorthamersc, Sofie ;
Van Laethem, Jean-Luc ;
Gidron, Yori .
CANCER EPIDEMIOLOGY, 2016, 40 :47-51
[9]   The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients [J].
De Couck, Marijke ;
van Brummelen, David ;
Schallier, Denis ;
De Greve, Jacques ;
Gidron, Yori .
ONCOLOGY REPORTS, 2013, 30 (05) :2435-2441
[10]   Heart Rate Variability Is a Predictor of Mortality in Chronic Kidney Disease: A Report from the CRIC Study [J].
Drawz, Paul E. ;
Babineau, Denise C. ;
Brecklin, Carolyn ;
He, Jiang ;
Kallem, Radhakrishna R. ;
Soliman, Elsayed Z. ;
Xie, Dawei ;
Appleby, Dina ;
Anderson, Amanda H. ;
Rahrnan, Mahboob .
AMERICAN JOURNAL OF NEPHROLOGY, 2013, 38 (06) :517-528
12345