β-homo-amino acid scan of angiotensin IV

被引：57

作者：

Lukaszuk, Aneta ^{[1
]}

Demaegdt, Heidi ^{[2
]}

Szemenyei, Erzsebet ^{[3
]}

Toth, Geza ^{[3
]}

Tymecka, Dagmara ^{[4
]}

Misicka, Aleksandra ^{[4
,5
]}

Karoyan, Philippe ^{[6
]}

Vanderheyden, Patrick ^{[2
]}

Vauquelin, Georges ^{[2
]}

Tourwe, Dirk ^{[1
]}

机构：

[1] Vrije Univ Brussels, Dept Organ Chem, B-1050 Brussels, Belgium

[2] Vrije Univ Brussels, Dept Mol & Biochem Pharmacol, B-1050 Brussels, Belgium

[3] Inst Biochem, Biol Res Ctr, H-6726 Szeged, Hungary

[4] Warsaw Univ, Fac Chem, PL-02093 Warsaw, Poland

[5] Polish Acad Sci, Med Res Ctr, PL-02106 Warsaw, Poland

[6] Univ Paris 06, CNRS, UMR 7613, Paris, France

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 07期

关键词：

D O I：

10.1021/jm701490g

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Angiotensin IV, a metabolite of angiotensin II, inhibits the enzyme insulin regulated aminopeptidase or IRAP and also, although with lower potency, aminopeptidase-N (AP-N). When both beta(2)-homo amino acid- and beta(3)-homo amino acid substitutions were used, allowed the identification of H-(R) beta(2)hVal-Tyr-Ile-His-Pro-beta(3) hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.

引用

页码：2291 / 2296

页数：6

共 38 条

[1] Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase
Albiston, AL
McDowall, SG
Matsacos, D
Sim, P
Clune, E
Mustafa, T
Lee, J
Mendelsohn, FAO
Simpson, RJ
Connolly, LM
Chai, SY
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) : 48623 - 48626
[2] Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands
Axen, Andreas
Lindeberg, Gunnar
Demaegdt, Heidi
Vauquelin, Georges
Karlen, Anders
Hallberg, Mathias
[J]. JOURNAL OF PEPTIDE SCIENCE, 2006, 12 (11) : 705 - 713
[3] Chai SY, 2004, CELL MOL LIFE SCI, V61, P2728, DOI 10.1007/s00018-004-4246-1
[4] Characterization of angiotensin IV-degrading enzymes and receptors on rat mesangial cells
Chansel, D
Czekalski, S
Vandermeersch, S
Ruffet, E
Fournié-Zaluski, MC
Ardaillou, R
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1998, 275 (04) : F535 - F542
[5] CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099
[6] de Gasparo M, 2000, PHARMACOL REV, V52, P415
[7] Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells:: characterization by [125I]Ang IV binding and catalytic activity
Demaegdt, H
Vanderheyden, P
De Backer, JP
Mosselmans, S
Laeremans, H
Le, MT
Kersemans, V
Yvette, MB
Vauquelin, G
[J]. BIOCHEMICAL PHARMACOLOGY, 2004, 68 (05) : 885 - 892
[8] Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N:: [125I]angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme
Demaegdt, Heidi
Lenaerts, Pieter-Jan
Swales, Julie
De Backer, Jean-Paul
Laeremans, Hilde
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 546 (1-3) : 19 - 27
[9] Frackenpohl J, 2001, CHEMBIOCHEM, V2, P445, DOI 10.1002/1439-7633(20010601)2:6<445::AID-CBIC445>3.0.CO
[10] 2-R

← 1 2 3 4 →