Do DC-Chol/DOPE-DNA complexes really form an inverted hexagonal phase?

被引：23

作者：

Caracciolo, G ^{[1
]}

Caminiti, R ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

CHEMICAL PHYSICS LETTERS | 2005年 / 411卷 / 4-6期

关键词：

D O I：

10.1016/j.cplett.2005.06.070

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Using synchrotron small angle X-ray scattering and energy dispersive X-ray diffraction, we have found that cationic liposomes made of the monovalent cationic lipid, 3-[N-(N,N-dimethylaminoethane)-carbamoyl]cholesterol (DC-Chol) and the neutral lipid dioleoylphosphatidylethanolamine (DOPE) condense DNA molecules forming complexes (DC-Chol/DOPE-DNA) which are not assembled in an inverted hexagonal structure as recently reported, but, conversely, form a well-ordered lamellar liquid-crystalline phase with distinct regimes of DNA packing density. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：327 / 332

页数：6

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