Spermatogonial Stem Cell Culture in Oncofertility

被引：17
作者：
David, Sherin [1 ]
Orwig, Kyle E. [1 ]
机构：
[1] Univ Pittsburgh, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Mol Genet & Dev Biol Grad Program,Sch Med, 204 Craft Ave, Pittsburgh, PA 15213 USA
来源：
UROLOGIC CLINICS OF NORTH AMERICA | 2020年 / 47卷 / 02期
关键词：
Spermatogonial stem cell culture; Fertility preservation; Male fertility; TESTICULAR TISSUE CRYOPRESERVATION; LONG-TERM PROLIFERATION; IN-VITRO; GERM-CELLS; FERTILITY PRESERVATION; SELF-RENEWAL; HUMAN TESTIS; NONOBSTRUCTIVE AZOOSPERMIA; OVARIAN TISSUE; MOUSE TESTIS;
D O I：
10.1016/j.ucl.2020.01.001
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility. SSC transplantation to regenerate spermatogenesis in infertile adult survivors of childhood cancers is a mature technology. However, the number of SSCs obtained in a biopsy of a prepubertal testis may be small. Therefore, methods to expand SSC numbers in culture before transplantation are needed. Here we review progress with human SSC culture.
引用
收藏
页码：227 / +
页数：19
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