Enantioselective α-Arylation of N-Acyloxazolidinones with Copper(II)-bisoxazoline Catalysts and Diaryliodonium Salts

被引：201

作者：

Bigot, Aurelien ^{[1
]}

Williamson, Alice E. ^{[1
]}

Gaunt, Matthew J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

SILYL ENOL ETHERS; CROSS-COUPLINGS; REGIOCONTROLLED SYNTHESIS; COPPER(II) COMPLEXES; PALLADIUM; PHENYLATION; EFFICIENT; CYCLOADDITION; ALDEHYDES; INDOLES;

D O I：

10.1021/ja206047h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for the catalytic enantioselective alpha-arylation of N-acyloxazolidinones with chiral copper(II)-bisoxazoline complexes and diaryliodonium salts is described. The mild catalytic conditions are operationally simple, produce valuable synthetic building blocks in excellent yields and enantioselectivities, and can be applied to the synthesis of important nonsteroidal anti-inflammatory agents and their analogues.

引用

页码：13778 / 13781

页数：4

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