Epicardial Application of Hydrogel with Amiodarone for Prevention of Postoperative Atrial Fibrillation in Patients After Coronary Artery Bypass Grafting

被引：13
|
作者：
Bockeria, O. L. [1 ,2 ]
Kanametov, T. N. [1 ,2 ]
Shvartz, V. A. [1 ,2 ]
Sokolskaya, M. A. [1 ,2 ]
Zhuginisov, D. Sh [1 ,2 ]
Sanakoev, M. K. [1 ,2 ]
Bockeria, L. A. [1 ,2 ]
机构：
[1] Bakulev Natl Med Res Ctr Cardiovasc Surg, Moscow, Russia
[2] Bakulev Natl Med Res Ctr Cardiovasc Surg, Dept Surg Treatment Interact Pathol, Moscow, Russia
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2020年 / 13卷 / 02期
基金：
俄罗斯科学基金会;
关键词：
Amiodarone-releasing hydrogel; Coronary artery bypass surgery; Postoperative atrial fibrillation; Prevention; Clinical study; MANAGEMENT;
D O I：
10.1007/s12265-019-09905-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The objective of this study was to assess the safety and efficacy of local epicardial application of amiodarone-releasing hydrogel for prevention of postoperative atrial fibrillation (POAF) in patients after coronary artery bypass grafting. Patients were randomized into two groups: with the application of amiodarone-releasing hydrogel and the control group. It included 60 patients (47 males, 13 females) (mean age of 62 +/- 8.5). POAF incidence differences were statistically significant between two groups: in the study group, the POAF incidence was 3.3%, while in the control group, the POAF incidence was 37% (p < 0.001). Statistically significant differences were revealed in the PQ interval duration. The risk of POAF incidence was calculated using the Cox regression model: the age and the application of amiodarone-releasing hydrogel application were statistically significant. Hospital length of stay in two groups was also different (p < 0.001). The age and the application of amiodarone-releasing hydrogel were statistically significant for POAF incidence.
引用
收藏
页码：191 / 198
页数：8
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