Epicardial Application of Hydrogel with Amiodarone for Prevention of Postoperative Atrial Fibrillation in Patients After Coronary Artery Bypass Grafting

被引：14

作者：

Bockeria, O. L. ^{[1
,2
]}

Kanametov, T. N. ^{[1
,2
]}

Shvartz, V. A. ^{[1
,2
]}

Sokolskaya, M. A. ^{[1
,2
]}

Zhuginisov, D. Sh ^{[1
,2
]}

Sanakoev, M. K. ^{[1
,2
]}

Bockeria, L. A. ^{[1
,2
]}

机构：

[1] Bakulev Natl Med Res Ctr Cardiovasc Surg, Moscow, Russia

[2] Bakulev Natl Med Res Ctr Cardiovasc Surg, Dept Surg Treatment Interact Pathol, Moscow, Russia

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2020年 / 13卷 / 02期

基金：

俄罗斯科学基金会;

关键词：

Amiodarone-releasing hydrogel; Coronary artery bypass surgery; Postoperative atrial fibrillation; Prevention; Clinical study; MANAGEMENT;

D O I：

10.1007/s12265-019-09905-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study was to assess the safety and efficacy of local epicardial application of amiodarone-releasing hydrogel for prevention of postoperative atrial fibrillation (POAF) in patients after coronary artery bypass grafting. Patients were randomized into two groups: with the application of amiodarone-releasing hydrogel and the control group. It included 60 patients (47 males, 13 females) (mean age of 62 +/- 8.5). POAF incidence differences were statistically significant between two groups: in the study group, the POAF incidence was 3.3%, while in the control group, the POAF incidence was 37% (p < 0.001). Statistically significant differences were revealed in the PQ interval duration. The risk of POAF incidence was calculated using the Cox regression model: the age and the application of amiodarone-releasing hydrogel application were statistically significant. Hospital length of stay in two groups was also different (p < 0.001). The age and the application of amiodarone-releasing hydrogel were statistically significant for POAF incidence.

引用

页码：191 / 198

页数：8

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