Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

被引：18

作者：

Delforge, Arnaud ^{[1
,2
]}

Georgiou, Irene ^{[1
,2
]}

Kremer, Adrian ^{[1
,2
]}

Wouters, Johan ^{[1
,2
]}

Bonifazi, Davide ^{[1
,2
,3
]}

机构：

[1] Univ Namur, Namur Res Coll, Rue Bruxelles 61, B-5000 Namur, Belgium

[2] Univ Namur, Dept Chem, Rue Bruxelles 61, B-5000 Namur, Belgium

[3] Cardiff Univ, Sch Chem, Pk Pl,Main Bldg, Cardiff CF10 3AT, S Glam, Wales

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 19期

关键词：

CROSS-COUPLING REACTIONS; C-N; ORGANIC-SYNTHESIS; NATURAL-PRODUCTS; VINYL HALIDES; COPPER; DERIVATIVES; PALLADIUM;

D O I：

10.1021/acs.orglett.6b02305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd-2(dba)(3)], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

引用

页码：4844 / 4847

页数：4

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