In situ microemulsion-gel obtained from bioadhesive hydroxypropyl methylcellulose films for transdermal administration of zidovudine

被引:15
作者
Souza de Araujo, Guilherme Rodolfo [1 ]
Porfirio, Leandro de Oliveira [1 ]
Santos Silva, Luiz Andre [1 ]
Santana, Danielle Gomes [1 ]
Barbosa, Paula Ferreira [2 ]
dos Santos, Cochiran Pereira [3 ]
Narain, Narendra [2 ]
Vitorino Sarmento, Victor Hugo [4 ]
Nunes, Rogeria de Souza [1 ]
Ting, Elizabeth [5 ]
Moreira Lira, Ana Amelia [1 ]
机构
[1] Univ Fed Sergipe, Dept Pharm, Av Marechal Rondon S-N, Sao Cristovao, Sergipe, Brazil
[2] Univ Fed Sergipe, Lab Flavor & Chromatog Anal, Sao Cristovao, Sergipe, Brazil
[3] Univ Fed Sergipe, Dept Phys, Sao Cristovao, Sergipe, Brazil
[4] Univ Fed Sergipe, Dept Chem, Itabaiana, Sergipe, Brazil
[5] Univ Fed Sergipe, Dept Morphol, Sao Cristovao, Sergipe, Brazil
关键词
Transdermal film; Zidovudine; Microemulsion; Microemulsion-gel; Polymer; Eucalyptus oil; SKIN PERMEATION; DERMAL DELIVERY; VITRO; FORMULATION; SYSTEMS; ENHANCERS; PATCH;
D O I
10.1016/j.colsurfb.2019.110739
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
This study aims to develop in situ microemulsion-gel (ME-Gel) obtained from hydroxypropyl methylcellulose (HPMC) films for transdermal administration of Zidovudine (AZT). Firstly, HPMC films containing propylene glycol (PG) and eucalyptus oil (EO) were obtained and characterized. Later, a pseudo-ternary phase diagram composed of water, EO, tween 80 and PG was obtained and one microemulsion (ME) with a similar proportion of the film components was obtained. ME was transformed in ME-Gel by the incorporation of HPMC. Finally, HPMC films were hydrated with Tween 80 solution to yield in situ ME-Gel and its effect on AZT skin permeation was compared with HPMC film hydrated with water (F5(hyd)). The results showed that the ME and ME-Gel presented a droplet size of 16.79 and 122.13 mu m, respectively, polydispersity index (PDI) < 0.39 and pH between 5.10 and 5.40. The incorporation of HPMC resulted in viscosity about 2 times higher than the use of ME. The presence of AZT did not alter the formulation properties. The in situ ME-Gel promoted a two-fold increase in the permeated amount of AZT compared to F5(hyd). The results suggest that it was possible to obtain an ME-Gel in situ from HPMC films and that its effect on transdermal permeation of AZT was significant.
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页数:6
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