Annealing processes of vacancy-type defects in epitaxial 6H SiC after 2 MeV electron irradiation and multiple He implantation have been investigated using positron annihilation spectroscopy. Vacancy-type defects are found to disappear in two annealing stages: at 500-800 degreesC and 1200-1500 degreesC. Silicon vacancies are the major positron trapping centers after electron irradiation. Two annealing stages after electron irradiation are attributed to the disappearance of isolated silicon vacancies and complexes associated with silicon vacancies, respectively. In He-irradiated SiC, divacancies are also generated in addition to silicon vacancies.