Effect of non-specific interactions on formation and stability of specific complexes

被引：6
|
作者：
Osmanovic, Dino [1 ]
Rabin, Yitzhak
机构：
[1] Bar Ilan Univ, Dept Phys, IL-52900 Ramat Gan, Israel
来源：
JOURNAL OF CHEMICAL PHYSICS | 2016年 / 144卷 / 20期
基金：
以色列科学基金会;
关键词：
PROTEIN-PROTEIN INTERACTIONS; PHASE-TRANSITIONS; METABOLIC ENZYMES; MOLTEN GLOBULE; DYNAMICS; REORGANIZATION; CONSTRAINTS; EVOLUTION;
D O I：
10.1063/1.4952981
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We introduce a simple model to describe the interplay between specific and non-specific interactions. We study the influence of various physical factors on the static and dynamic properties of the specific interactions of our model and show that contrary to intuitive expectations, non-specific interactions can assist in the formation of specific complexes and increase their stability. We then discuss the relevance of these results for biological systems. Published by AIP Publishing.
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页数：6
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