An improved method of ring closing metathesis in the presence of basic amines: application to the formal synthesis of (+)-lentiginosine and other piperidines and carbamino sugar analogs

被引:26
作者
Lahiri, Rima [1 ]
Kokatla, Hari Prasad [1 ]
Vankar, Yashwant D. [1 ]
机构
[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India
关键词
Metathesis; Basic amines; Azasugars; Lentiginosine; OLEFIN METATHESIS; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; IMINO SUGARS; 1-DEOXYNOJIRIMYCIN ANALOGS; STEREOSELECTIVE-SYNTHESIS; GLUCOSIDASE INHIBITOR; D-GALACTOSE; HETEROCYCLES; ROUTE;
D O I
10.1016/j.tetlet.2010.12.020
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A generalized method for performing ring closing metathesis in the presence of basic amines has been established and successfully used in the formal synthesis of (+)-lentiginosine as well as some valuable intermediates for the synthesis of several other azasugars and aminocyclitols. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:781 / 786
页数:6
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