Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

被引：44

作者：

Nguyen, Thi Ngoc Anh ^{[1
]}

Dao, Trong Tuan ^{[1
]}

Tung, Bui Thanh ^{[1
]}

Choi, Hwanwon ^{[2
]}

Kim, Eunhee ^{[2
]}

Park, Junsoo ^{[3
]}

Lim, Seong-Il ^{[4
]}

Oh, Won Keun ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Project Team BK21, Kwangju 501759, South Korea

[2] Choong Ang Vaccine Lab, Taejon 305348, South Korea

[3] Yonsei Univ, Div Biol Sci & Technol, Wonju 220100, South Korea

[4] Korea Food Res Inst, Tradit Food Res Grp, Songnam 463746, South Korea

来源：

FOOD CHEMISTRY | 2011年 / 124卷 / 02期

关键词：

Influenza A; Neuraminidase inhibitors; Oseltamivir resistance; Vitis amurensis; Oligostilbenes; COMBINATION THERAPY; VIRUS INFECTION; VINIFERA KYOHOU; OLIGOSTILBENES; MICE; RESVERATROL; RIMANTADINE; COIGNETIAE; ROOTS; CELLS;

D O I：

10.1016/j.foodchem.2010.06.049

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：437 / 443

页数：7

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