Biologics in Pediatric Rheumatology: Quo Vadis?

被引：12

作者：

Sterba, Yonit ^{[1
]}

Ilowite, Norman ^{[1
]}

机构：

[1] Childrens Hosp Montefiore, Div Pediat Rheumatol, 3415 Bainbridge Ave, Bronx, NY 10467 USA

来源：

CURRENT RHEUMATOLOGY REPORTS | 2016年 / 18卷 / 07期

关键词：

TNF inhibitors; IL-1; inhibitors; IL-6; Abatacept; Rituximab; Tofacitinib; Juvenile idiopathic arthritis (JIA); JUVENILE IDIOPATHIC ARTHRITIS; ACTIVE PSORIATIC-ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; WITHDRAWAL TRIAL; EFFICACY; SAFETY; METHOTREXATE; MULTICENTER;

D O I：

10.1007/s11926-016-0593-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The past two decades have brought immense satisfaction to pediatric rheumatologists and families of children with rheumatologic diseases. We have been able to better classify, recognize, and diagnose rheumatologic diseases, but most importantly, the discovery of biologic therapies and their efficacy and relative safety in treating multiple rheumatologic conditions, improving quality of life for the patients we care for. We will review the advances of the past two decades and discuss potential areas for new discoveries.

引用

页数：6

共 40 条

[11] Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease [J].

Dale, Russell C. ;

Brilot, Fabienne ;

Duffy, Lisa V. ;

Twilt, Marinka ;

Waldman, Amy T. ;

Narula, Sona ;

Muscal, Eyal ;

Deiva, Kumaran ;

Andersen, Erik ;

Eyre, Michael R. ;

Eleftheriou, Despina ;

Brogan, Paul A. ;

Kneen, Rachel ;

Alper, Gulay ;

Anlar, Banu ;

Wassmer, Evangeline ;

Heineman, Kirsten ;

Hemingway, Cheryl ;

Riney, Catherine J. ;

Kornberg, Andrew ;

Tardieu, Marc ;

Stocco, Amber ;

Banwell, Brenda ;

Gorman, Mark P. ;

Benseler, Susanne M. ;

Lim, Ming .

NEUROLOGY, 2014, 83 (02) :142-150

[12] Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis [J].

De Benedetti, Fabrizio ;

Brunner, Hermine I. ;

Ruperto, Nicolino ;

Kenwright, Andrew ;

Wright, Stephen ;

Calvo, Inmaculada ;

Cuttica, Ruben ;

Ravelli, Angelo ;

Schneider, Rayfel ;

Woo, Patricia ;

Wouters, Carine ;

Xavier, Ricardo ;

Zemel, Lawrence ;

Baildam, Eileen ;

Burgos-Vargas, Ruben ;

Dolezalova, Pavla ;

Garay, Stella M. ;

Merino, Rosa ;

Joos, Rik ;

Grom, Alexei ;

Wulffraat, Nico ;

Zuber, Zbigniew ;

Zulian, Francesco ;

Lovell, Daniel ;

Martini, Alberto .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (25) :2385-2395

[13] Methotrexate Withdrawal at 6 vs 12 Months in Juvenile Idiopathic Arthritis in Remission A Randomized Clinical Trial [J].

Foell, Dirk ;

Wulffraat, Nico ;

Wedderburn, Lucy R. ;

Wittkowski, Helmut ;

Frosch, Michael ;

Gerss, Joachim ;

Stanevicha, Valda ;

Mihaylova, Dimitrina ;

Ferriani, Virginia ;

Tsakalidou, Florence Kanakoudi ;

Foeldvari, Ivan ;

Cuttica, Ruben ;

Gonzalez, Benito ;

Ravelli, Angelo ;

Khubchandani, Raju ;

Oliveira, Sheila ;

Armbrust, Wineke ;

Garay, Stella ;

Vojinovic, Jelena ;

Norambuena, Ximena ;

Gamir, Maria Luz ;

Garcia-Consuegra, Julia ;

Lepore, Loredana ;

Susic, Gordana ;

Corona, Fabrizia ;

Dolezalova, Pavla ;

Pistorio, Angela ;

Martini, Alberto ;

Ruperto, Nicolino ;

Roth, Johannes .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (13) :1266-1273

[14]

Gabriele S, 2013, PEDIATR RHEUMATOL, V11, P16, DOI [10.1186/1546-0096-11-16, DOI 10.1186/1546-0096-11-16]

[15] Usefulness of Adalimumab in the Treatment of Refractory Uveitis Associated with Juvenile Idiopathic Arthritis [J].

Garcia-De-Vicuna, Carmen ;

Diaz-Llopis, Manuel ;

Salom, David ;

Bou, Rosa ;

Diaz-Cascajosa, Jesus ;

Cordero-Coma, Miguel ;

Ortega, Gabriela ;

Ortego-Centeno, Norberto ;

Suarez-De-Figueroa, Marta ;

Cruz-Martinez, Juan ;

Fonollosa, Alex ;

Blanco, Ricardo ;

Maria Garcia-Aparicio, Angel ;

Benitez-Del-Castillo, Jose M. ;

Anton, Jordi .

MEDIATORS OF INFLAMMATION, 2013, 2013

[16] Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibition [J].

Goldbach-Mansky, Raphaela ;

Dailey, Natalie J. ;

Canna, Scott W. ;

Gelabert, Ana ;

Jones, Janet ;

Rubin, Benjamin I. ;

Kim, H. Jeffrey ;

Brewer, Carmen ;

Zalewski, Christopher ;

Wiggs, Edythe ;

Hill, Suvimol ;

Turner, Maria L. ;

Karp, Barbara I. ;

Aksentijevich, Ivona ;

Pucino, Frank ;

Penzak, Scott R. ;

Haverkamp, Margje H. ;

Stein, Leonard ;

Adams, Barbara S. ;

Moore, Terry L. ;

Fuhlbrigge, Robert C. ;

Shaham, Bracha ;

Jarvis, James N. ;

O'Neil, Kathleen ;

Vehe, Richard K. ;

Beitz, Laurie O. ;

Gardner, Gregory ;

Hannan, William P. ;

Warren, Robert W. ;

Horn, William ;

Cole, Joe L. ;

Paul, Scott M. ;

Hawkins, Philip N. ;

Pham, Tuyet Hang ;

Snyder, Christopher ;

Wesley, Robert A. ;

Hoffmann, Steven C. ;

Holland, Steven M. ;

Butman, John A. ;

Kastner, Daniel L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (06) :581-592

[17] The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort [J].

Guzman, Jaime ;

Oen, Kiem ;

Tucker, Lori B. ;

Huber, Adam M. ;

Shiff, Natalie ;

Boire, Gilles ;

Scuccimarri, Rosie ;

Berard, Roberta ;

Tse, Shirley M. L. ;

Morishita, Kimberly ;

Stringer, Elizabeth ;

Johnson, Nicole ;

Levy, Deborah M. ;

Duffy, Karen Watanabe ;

Cabral, David A. ;

Rosenberg, Alan M. ;

Larche, Maggie ;

Dancey, Paul ;

Petty, Ross E. ;

Laxer, Ronald M. ;

Silverman, Earl ;

Miettunen, Paivi ;

Chetaille, Anne-Laure ;

Haddad, Elie ;

Houghton, Kristin ;

Spiegel, Lynn ;

Turvey, Stuart E. ;

Schmeling, Heinrike ;

Lang, Bianca ;

Ellsworth, Janet ;

Ramsey, Suzanne ;

Bruns, Alessandra ;

Campillo, Sarah ;

Benseler, Susanne ;

Chedeville, Gaelle ;

Schneider, Rayfel ;

Yeung, Rae ;

Duffy, Ciaran M. .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (10) :1854-1860

[18] Improvement of functional ability in children with juvenile idiopathic arthritis by treatment with etanercept [J].

Halbig, M. ;

Horneff, G. .

RHEUMATOLOGY INTERNATIONAL, 2009, 30 (02) :229-238

[19] Safety and Efficacy of Belimumab to Treat Systemic Lupus Erythematosus in Academic Clinical Practices [J].

Hui-Yuen, Joyce S. ;

Reddy, Arthi ;

Taylor, Jennifer ;

Li, Xiaoqing ;

Eichenfield, Andrew H. ;

Bermudez, Liza M. ;

Starr, Amy J. ;

Imundo, Lisa F. ;

Buyon, Jill ;

Furie, Richard A. ;

Kamen, Diane L. ;

Manzi, Susan ;

Petri, Michelle ;

Ramsey-Goldman, Rosalind ;

van Vollenhoven, Ronald F. ;

Wallace, Daniel J. ;

Askanase, Anca .

JOURNAL OF RHEUMATOLOGY, 2015, 42 (12) :2288-2295

[20] Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis [J].

Ilowite, Norman T. ;

Prather, Kristi ;

Lokhnygina, Yuliya ;

Schanberg, Laura E. ;

Elder, Melissa ;

Milojevic, Diana ;

Verbsky, James W. ;

Spalding, Steven J. ;

Kimura, Yukiko ;

Imundo, Lisa F. ;

Punaro, Marilynn G. ;

Sherry, David D. ;

Tarvin, Stacey E. ;

Zemel, Lawrence S. ;

Birmingham, James D. ;

Gottlieb, Beth S. ;

Miller, Michael L. ;

O'Neil, Kathleen ;

Ruth, Natasha M. ;

Wallace, Carol A. ;

Singer, Nora G. ;

Sandborg, Christy I. .

ARTHRITIS & RHEUMATOLOGY, 2014, 66 (09) :2570-2579

← 1 2 3 4 →