Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda

被引：8

作者：

Nabukalu, Dorean ^{[1
]}

Reniers, Georges ^{[2
,3
]}

Risher, Kathryn A. ^{[2
]}

Blom, Sylvia ^{[2
]}

Slaymaker, Emma ^{[2
]}

Kabudula, Chodziwadziwa ^{[3
]}

Zaba, Basia ^{[2
]}

Nalugoda, Fred ^{[1
,4
]}

Kigozi, Godfrey ^{[1
,4
]}

Makumbi, Fred ^{[1
]}

Serwadda, David ^{[1
]}

Reynolds, Steven J. ^{[5
,6
]}

Marston, Milly ^{[2
]}

Eaton, Jeffrey W. ^{[7
]}

Gray, Ron ^{[1
,6
]}

Wawer, Maria ^{[1
,6
]}

Sewankambo, Nelson ^{[1
,4
]}

Lutalo, Tom ^{[1
,8
]}

机构：

[1] Rakai Hlth Sci Program, Kalisizo, Uganda

[2] London Sch Hyg & Trop Med, Dept Populat Hlth, London, England

[3] Univ Witwatersrand, Sch Publ Hlth, Johannesburg, South Africa

[4] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda

[5] NIH, Bldg 10, Bethesda, MD 20892 USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[7] Imperial Coll London, Dept Infect Dis Epidemiol, London, England

[8] Uganda Virus Res Inst, Entebbe, Uganda

来源：

POPULATION STUDIES-A JOURNAL OF DEMOGRAPHY | 2020年 / 74卷 / 01期

基金：

英国医学研究理事会;

关键词：

antiretroviral therapy (ART); HIV; mortality; Rakai; Uganda; HIV-INFECTION; LIFE EXPECTANCY; AIDS-PREVENTION; AFRICA; SEX; DISTRICT; DISEASE; TRENDS; IMPACT;

D O I：

10.1080/00324728.2019.1595099

中图分类号：

C921 [人口统计学];

学科分类号：

摘要：

There are limited data on the impact of antiretroviral therapy (ART) on population-level adult mortality in sub-Saharan Africa. We analysed data for 2000-14 from the Rakai Community Cohort Study (RCCS) in Uganda, where free ART was scaled up after 2004. Using non-parametric and parametric (Weibull) survival analysis, we estimated trends in average person-years lived between exact ages 15 and 50, per capita life-years lost to HIV, and the mortality hazards of people living with HIV (PLHIV). Between 2000 and 2014, average adult life-years lived before age 50 increased significantly, from 26.4 to 33.5 years for all women and from 28.6 to 33.8 years for all men. As of 2014, life-years lost to HIV had declined significantly, to 1.3 years among women and 0.4 years among men. Following the roll-out of ART, mortality reductions among PLHIV were initially larger in women than men, but this is no longer the case.

引用

页码：93 / 102

页数：10

共 33 条

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