CONCISE SYNTHESIS OF (±)-CEPHALOTAXINE

被引：0

作者：

Zhan, Jian ^{[1
,2
,3
]}

Ding, Huili ^{[1
]}

Fan, Yuxue ^{[1
]}

Chen, Hui ^{[1
,2
]}

Dai, Hongxia ^{[1
,2
]}

Jing, Ming ^{[1
,2
]}

机构：

[1] Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China

[2] Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China

[3] Key Lab Chem & Qual TCM Coll Gansu Prov, Lanzhou 730000, Peoples R China

来源：

HETEROCYCLES | 2022年 / 106卷 / 01期

基金：

中国国家自然科学基金;

关键词：

HIGHLY EFFICIENT SYNTHESIS; FORMAL SYNTHESIS; CEPHALOTAXUS ALKALOIDS; (-)-CEPHALOTAXINE; REARRANGEMENT;

D O I：

10.3987/COM-22-14774

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of 1-azaspiro[4.4]nonane framework was achieved via the key Stevens rearrangement reaction of the Weinreb amide. And the subsequent steps mediated by the carbonyl of Weinreb amide led to the concise formal synthesis of (& PLUSMN;)-cephalotaxine. Further development and application of asymmetric Stevens rearrangement of the Weinreb amide are underway.

引用

页码：166 / 173

页数：8

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