Fatal aortic pseudoaneurysm from disseminated Mycobacterium kansasii infection: case report

被引：10

作者：

Ehsani, Laleh ^{[1
]}

Reddy, Sujan C. ^{[2
]}

Mosunjac, Mario ^{[1
]}

Kraft, Colleen S. ^{[1
,2
]}

Guarner, Jeannette ^{[1
,2
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[2] Emory Univ, Div Infect Dis, Atlanta, GA 30322 USA

来源：

HUMAN PATHOLOGY | 2015年 / 46卷 / 03期

关键词：

Mycobacterium kansasii; Aortic pseudoaneurysm; Granuloma; Myelodysplastic syndrome; MonoMAC syndrome; GATA2; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; SPORADIC MONOCYTOPENIA; AUTOSOMAL-DOMINANT; MONOMAC SYNDROME; MYELODYSPLASIA; GATA2; MUTATIONS; FEATURES; DISEASE;

D O I：

10.1016/j.humpath.2014.11.005

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mycobacterium kansasii is a photochromogenic, slow-growing mycobacterium species that can cause pulmonary infection in patients with predisposing lung diseases, as well as extrapulmonary or disseminated disease in immunosuppressed patients. We describe a patient with a myelodysplastic syndrome, disseminated M kansasii infection, and ruptured aortic aneurysm. He had a recent diagnosis of mycobacterium cavitary lung lesions and was transferred to our facility for possible surgical intervention of an aortic aneurysm. Few hours after admission, the patient suddenly collapsed and died despite resuscitation efforts. A complete autopsy was performed and showed ruptured ascending aortic pseudoaneurysm with hemopericardium, disseminated necrotizing and nonnecrotizing granulomas with acid-fast bacilli in the aortic wall, lungs, heart, liver, spleen, and kidneys. Further genetic studies were consistent with monocytopenia and mycobacterial infection syndrome. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：467 / 470

页数：4

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