Short and practical synthesis of N′,N′-Disubstituted N-aryl-1,2-ethylenediamines by a decarboxylative ring-opening reaction under nucleophilic conditions

被引：5

作者：

Morita, Yasuhiro ^{[1
]}

Ishigaki, Takeshi ^{[1
]}

Kawamura, Kuniaki ^{[1
]}

Iseki, Katsuhiko ^{[1
]}

机构：

[1] Toray Industries Ltd, Pharmaceut Res Labs, Kanagawa 2488555, Japan

来源：

SYNTHESIS-STUTTGART | 2007年 / 16卷 / 16期

关键词：

amines; cyclization; heterocycles; piperidines; ring opening;

D O I：

10.1055/s-2007-983810

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward and practical synthesis of N',N'-disubstituted N-aryl-1,2-ethylenediamines, starting from anilines, via Naryloxazolidin-2-ones is described. A decarboxylative ring-opening reaction of N-aryloxazolidin-2-ones, using aliphatic secondary amines, is the key step in this procedure. A one-pot synthesis of Naryloxazolidin-2-ones is also described. N',N'-Disubstituted N-aryl-1,2-ethylenediamines are a useful building block for biologically active compounds.

引用

页码：2517 / 2523

页数：7

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