DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A

被引：38
作者：
Brown, Amy L.
Odell, Edward W.
Mantle, Peter G. [1 ]
机构：
[1] Imperial Coll London, Ctr Environm Policy, London SW7 2AZ, England
[2] Guys Hosp, Dept Oral Pathol, London SE1 9RT, England
来源：
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2007年 / 59卷 / 02期
关键词：
ochratoxin a; nuclear ploidy; carcinoma; adenoma; nephrotoxicity; renal cancer; testicular cancer; karyomegaly;
D O I：
10.1016/j.etp.2007.05.001
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
DNA ploidy distribution, measured in experimental renal tumours that occurred in twelve ageing male Fischer rats derived from carcinogenicity experiments on ochratoxin A (OTA) in response to chronic dietary exposure, was diploid in all renal adenomas and aneuploid in all carcinomas, correlating with their typical organised and disorganised histopathology, respectively. Aneuploidy was also detected in renal tissue in which karyomegaly, induced by OTA, was analogous to that caused by the fungus Penicillium polonicum. Thus, the experimental rat renal carcinoma could arise within an adenoma directly from certain persistent karyornegalic tubular epithelial cells long after their particular genetic damage has been caused during a protracted period of OTA insult. (C) 2007 Elsevier GmbH. All rights reserved.
引用
收藏
页码：85 / 95
页数：11
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