Guidelines for the management of nilotinib (Tasigna®)-induced side effects in chronic myelogenous leukemia: recommendations of French Intergroup of CML (Fi-LMC group)

被引:8
作者
Etienne, G. [2 ,7 ]
Milpied, B. [3 ]
Rea, D. [4 ,7 ]
Rigal-Huguet, F. [5 ,7 ]
Tulliez, M. [6 ,7 ]
Nicolini, F. -E. [1 ,7 ]
机构
[1] Hop Edouard Herriot, Serv Hematol Clin, F-69437 Lyon 03, France
[2] Ctr Reg Lutte Canc, Inst Bergonie, F-33076 Bordeaux, France
[3] Hop St Andre, Serv Dermatol, F-33075 Bordeaux, France
[4] Hop St Louis, AP HP, Serv Malad Sang, F-75475 Paris 15, France
[5] Hop Purpan, Serv Hematol Clin, F-31300 Toulouse, France
[6] Hop Henri Mondor, AP HP, Serv Hematol Biol, F-94000 Creteil, France
[7] CHU La Miletrie, Fi LMC, F-86021 Poitiers, France
关键词
CML; imatinib; nilotinib; TKI2; side effects; CHRONIC MYELOID-LEUKEMIA; TYROSINE KINASE INHIBITOR; IMATINIB-RESISTANT; FORMERLY AMN107; PREGNANCY;
D O I
10.1684/bdc.2010.1136
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nilotinib (Tasigna (R)) is a second-generation BCR-ABL kinase inhibitor, recently introduced and used for the treatment of chronic or accelerated phase CML patients, intolerant or resistant to imatinib. This treatment represents and important step forward for the disease control of such patients but can lead to side effects, sometimes serious, which can limit its optimal use. We propose here some guidelines that might be of help in daily practice, in order to manage properly these side effects.
引用
收藏
页码:997 / 1009
页数:13
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