Asymmetric synthesis of polyfunctionalized piperidines: Substitution at the C-4 position.

被引：6

作者：

Billon-Souquet, F

Martens, T

Royer, J ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Univ Paris 05, Lab Chim Analyt & Electrochim, Fac Pharm, UMR 8638, F-75782 Paris, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(99)00625-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The electrochemical bis-bromination of the chiral building block 1 followed by a dehydrobromination step allowed the preparation of a bromopiperideine 3. The stereoselective addition of nucleophiles onto this key intermediate permitted the synthesis of various 4-substituted piperidine derivatives. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3731 / 3734

页数：4

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