SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF 1H-PYRAZOLINES BEARING 5-BROMO-3-AMINO BENZOFURAN

被引：0

作者：

Durgad, Siddanna ^{[1
]}

Kumbhar, Mahesh

Basawaraj, Raga ^{[2
]}

Srujana, T. Susan

Barbole, Pruthviraj

机构：

[1] RMESs Coll Pharm, Postgrad Ctr, Dept Pharmaceut Chem, Gulbarga 585101, Karnataka, India

[2] Karnataka Coll Pharm, Post Grad Ctr, Dept Pharmaceut Chem, Bidar 585403, Karnataka, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 21卷 / 02期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Bromo-3-amino-2-acetyl banzofuran 3 was prepared by the interaction of 5-bromosalicylonitrile and chloroacetone in presence of anhyd potassium carbonate in dry acetone. The compound 3 was treated with different substituted aromatic aldehydes in ethanol in presence of strong alkali to give 5-bromo-3-amino-2-arylidene acetylbenzofurans (4a-e). 5-(3-Amino-5-bromobenzofuran)-3-aryl-2-pyrazolines (5a-e) were synthesized by the reaction of 5-bromo-3-amino-2-arylidene acetylbenzofurans (4a-e) with hydrazine hydrate. The reaction of compounds (5a-e) with chloroacetyl chloride in presence of triethylamine in dry toluene furnished 5-aryl-[5'-bromo-3'-(chloroacetyl)-aminobenzofuran-2-yl]-1H-pyrazolines (6a-e). All synthesized compounds were screened for their antimicrobial activities and some selected benzofuran pyrazoline derivatives were screened for antiinflammatory activities.

引用

页码：167 / 172

页数：6