Mathematical models of cancer stem cells

被引：80

作者：

Michor, Franziska ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10065 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2008年 / 26卷 / 17期

关键词：

D O I：

10.1200/JCO.2007.15.2421

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human cancers are thought to be sustained in their growth by a pathologic counterpart of normal adult stem cells: cancer stem cells. This concept was first developed in human myeloid leukemias and is today being extended to solid tumors such as breast and brain cancers. A quantitative understanding of cancer stem cells requires a mathematical framework to describe the dynamics of cancer initiation and progression, the response to treatment, and the evolution of resistance. In this review, I use chronic myeloid leukemia as an example to discuss how mathematical and computational techniques have been used to gain insights into the biology of cancer stem cells.

引用

页码：2854 / 2861

页数：8

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