MYCL promotes the progression of triple-negative breast cancer by activating the JAK/STAT3 pathway

被引：3

作者：

Jiang, Hongnan ^{[1
]}

Li, Xiaojun ^{[2
]}

Wang, Wei ^{[1
]}

Hu, Yaofeng ^{[1
]}

Ren, Dongliang ^{[1
]}

机构：

[1] Shanxi Med Univ, Hosp 2, Dept Breast Surg, Taiyuan 030001, Shanxi, Peoples R China

[2] Shanxi Med Univ, Hosp 2, Dept Radiol, Taiyuan 030001, Shanxi, Peoples R China

来源：

ONCOLOGY REPORTS | 2022年 / 48卷 / 05期

关键词：

MYCL proto-oncogene; triple-negative breast cancer; proliferation; migration; JAK; STAT3; pathway; PROLIFERATION; EXPRESSION; APOPTOSIS; DISEASE;

D O I：

10.3892/or.2022.8418

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study aimed to investigate the underlying regulatory mechanism of MYCL proto-oncogene (MYCL) in triple-negative breast cancer (TNBC) progression. In vitro experiments were performed to confirm the functional roles of MYCL in TNBC, and its effects on the JAK/STAT3 pathway through flow cytometric analysis, colony formation, wound healing and Transwell assays. In addition, the GSE45498 dataset demonstrated that MYCL was upregulated in TNBC and that it was significantly related to poor survival of patients with TNBC. Knockdown of MYCL induced the apoptosis, and suppressed the proliferation, migration and invasion of TNBC cells by inhibiting the JAK/STAT3 pathway. Notably, MYCL could activate the JAK/STAT3 pathway, whereas inhibition of the JAK/STAT3 pathway could eliminate the effect of MYCL on TNBC cells. Knockdown of MYCL also suppressed the growth of TNBC xenograft tumors. In conclusion, MYCL could promote TNBC progression by activating the JAK/STAT3 pathway.

引用

页数：11

共 45 条

[1] N-Myc mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer [J].

Berger, Adeline ;

Brady, Nicholas J. ;

Bareja, Rohan ;

Robinson, Brian ;

Conteduca, Vincenza ;

Augello, Michael A. ;

Ruca, Loredana ;

Ahmed, Adnan ;

Dardenne, Etienne ;

Lu, Xiaodong ;

Hwang, Inah ;

Bagadion, Alyssa M. ;

Sboner, Andrea ;

Elemento, Olivier ;

Paik, Jihye ;

Yu, Jindan ;

Barbieri, Christopher E. ;

Dephoure, Noah ;

Beltran, Himisha ;

Rickman, David S. .

JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (09) :3924-3940

[2] Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer [J].

Bruner, Heather C. ;

Derksen, Patrick W. B. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2018, 10 (03)

[3] MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer [J].

Burchett, Jamison B. ;

Knudsen-Clark, Amelia M. ;

Altman, Brian J. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)

[4] Integrated MicroRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer [J].

Cascione, Luciano ;

Gasparini, Pierluigi ;

Lovat, Francesca ;

Carasi, Stefania ;

Pulvirenti, Alfredo ;

Ferro, Alfredo ;

Alder, Hansjuerg ;

He, Gang ;

Vecchione, Andrea ;

Croce, Carlo M. ;

Shapiro, Charles L. ;

Huebner, Kay .

PLOS ONE, 2013, 8 (02)

[5] MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis [J].

Chen, Fengxia ;

Wang, Qingqing ;

Yu, Xiaoyan ;

Yang, Ningning ;

Wang, Yuan ;

Zeng, Yangyang ;

Zheng, Zhewen ;

Zhou, Fuxiang ;

Zhou, Yunfeng .

CELL DEATH & DISEASE, 2021, 12 (04)

[6] Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer [J].

Ciampricotti, Metamia ;

Karakousi, Triantafyllia ;

Richards, Allison L. ;

Quintanal-Villalonga, Alvaro ;

Karatza, Angeliki ;

Caeser, Rebecca ;

Costa, Emily A. ;

Allaj, Viola ;

Manoj, Parvathy ;

Spainhower, Kyle B. ;

Kombak, Faruk E. ;

Sanchez-Rivera, Francisco J. ;

Jaspers, Janneke E. ;

Zavitsanou, Anastasia-Maria ;

Maddalo, Danilo ;

Ventura, Andrea ;

Rideout, William M. ;

Akama-Garren, Elliot H. ;

Jacks, Tyler ;

Donoghue, Mark T. A. ;

Sen, Triparna ;

Oliver, Trudy G. ;

Poirier, John T. ;

Papagiannakopoulos, Thales ;

Rudin, Charles M. .

CANCER DISCOVERY, 2021, 11 (12) :3214-3229

[7] Expression Clinical Significance of Claudin-7, PDL-1, PTEN, c-Kit, c-Met, c-Myc, ALK, CK5/6, CK17, p53, EGFR, Ki67, p63 in Triple-negative Single Centre Prospective Observational Study [J].

Constantinou, Chloe ;

Papadopoulos, Savvas ;

Karyda, Eirini ;

Alexopoulos, Athanasios ;

Agnanti, Niki ;

Batistatou, Anna ;

Harisis, Haris .

IN VIVO, 2018, 32 (02) :303-311

[8] Cadherins function during the collective cell migration of Xenopus Cranial Neural Crest cells: revisiting the role of E-cadherin [J].

Cousin, Helene .

MECHANISMS OF DEVELOPMENT, 2017, 148 :79-88

[9] Multi-Gene Testing Overview with a Clinical Perspective in Metastatic Triple-Negative Breast Cancer [J].

Dameri, Martina ;

Ferrando, Lorenzo ;

Cirmena, Gabriella ;

Vernieri, Claudio ;

Pruneri, Giancarlo ;

Ballestrero, Alberto ;

Zoppoli, Gabriele .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)

[10] Triple-negative breast cancer: Clinical features and patterns of recurrence [J].

Dent, Rebecca ;

Trudeau, Maureen ;

Pritchard, Kathleen I. ;

Hanna, Wedad M. ;

Kahn, Harriet K. ;

Sawka, Carol A. ;

Lickley, Lavina A. ;

Rawlinson, Ellen ;

Sun, Ping ;

Narod, Steven A. .

CLINICAL CANCER RESEARCH, 2007, 13 (15) :4429-4434

← 1 2 3 4 5 →