Centriolar satellites: Busy orbits around the centrosome

被引:65
作者
Baerenz, Felix [1 ]
Mayilo, Dmytro [1 ]
Gruss, Oliver J. [1 ]
机构
[1] Univ Heidelberg ZMBH, Zentrum Mol Biol, DKFZ ZMBH Allianz, D-69120 Heidelberg, Germany
关键词
Centrosome; Centriolar satellite; Pericentriolar satellites; PCM1; Neurogenesis; Ciliogenesis; BARDET-BIEDL-SYNDROME; INTERKINETIC NUCLEAR MIGRATION; MITOTIC SPINDLE ORGANIZATION; HUMAN OBESITY SYNDROME; CELL-CYCLE; MOLECULAR CHARACTERIZATION; MICROTUBULE ORGANIZATION; PROGENITOR PROLIFERATION; NEURONAL MIGRATION; BIPOLAR DISORDER;
D O I
10.1016/j.ejcb.2011.07.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Since its first description by Theodor Boveri in 1888, the centrosome has been studied intensely, and it revealed detailed information about its structure, molecular composition and its various functions. The centrosome consists of two centrioles, which generally appear in electron microscopy as barrel-shaped structures usually composed of nine microtubule triplets. An amorphous mass of pericentriolar material surrounds the centrioles and accumulates many proteins important for the integrity and function of centrosomes, such as the gamma-tubulin ring complex (gamma-TuRC) that mediates microtubule nucleation and capping. In animal somatic cells, the centrosome generally accounts for the major microtubule organizing center, and the duplicated pair of centrosomes determines the poles of the microtubule-based mitotic spindle. Despite detailed insights into the centrosome's structure and function, it has been a complete mystery until a few years ago how centrosomes duplicate and assemble. Moreover, it is still largely unclear if and how centrosomal proteins or protein complexes are exchanged, replaced or qualitatively altered. Previously identified cytoplasmic granules, named "pericentriolar" or "centriolar satellites", might fulfil such functions in protein targeting and exchange, and communication between the centrosomes and the cytoplasm. In this review, we summarize current knowledge about the structure, molecular composition and possible roles of the satellites that seem to surround the core of the centrosome in most animal cells. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码:983 / 989
页数:7
相关论文
共 81 条
[41]   The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole [J].
Kim, Kyeongmi ;
Rhee, Kunsoo .
JOURNAL OF CELL SCIENCE, 2011, 124 (03) :338-347
[42]   Par6α Interacts with the Dynactin Subunit p150Glued and Is a Critical Regulator of Centrosomal Protein Recruitment [J].
Kodani, Andrew ;
Tonthat, Vinh ;
Wu, Beibei ;
Suetterlin, Christine .
MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (19) :3376-3385
[43]   Centriolar satellites: Molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis [J].
Kubo, A ;
Sasaki, H ;
Yuba-Kubo, A ;
Tsukita, S ;
Shiina, N .
JOURNAL OF CELL BIOLOGY, 1999, 147 (05) :969-979
[44]  
KURIYAMA R, 1981, J CELL SCI, V49, P33
[45]   Genome scan meta-analysis of schizophrenia and bipolar disorder, part II:: Schizophrenia [J].
Lewis, CM ;
Levinson, DF ;
Wise, LH ;
DeLisi, LE ;
Straub, RE ;
Hovatta, I ;
Williams, NM ;
Schwab, SG ;
Pulver, AE ;
Faraone, SV ;
Brzustowicz, LM ;
Kaufmann, CA ;
Garver, DL ;
Gurling, HMD ;
Lindholm, E ;
Coon, H ;
Moises, HW ;
Byerley, W ;
Shaw, SH ;
Mesen, A ;
Sherrington, R ;
O'Neill, FA ;
Walsh, D ;
Kendler, KS ;
Ekelund, J ;
Paunio, T ;
Lönnqvist, J ;
Peltonen, L ;
O'Donovan, MC ;
Owen, MJ ;
Wildenauer, DB ;
Maier, W ;
Nestadt, G ;
Blouin, JL ;
Antonarakis, SE ;
Mowry, BJ ;
Silverman, JM ;
Crowe, RR ;
Cloninger, CR ;
Tsuang, MT ;
Malaspina, D ;
Harkavy-Friedman, JM ;
Svrakic, DM ;
Bassett, AS ;
Holcomb, J ;
Kalsi, G ;
McQuillin, A ;
Brynjolfson, J ;
Sigmundsson, T ;
Petursson, H .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (01) :34-48
[46]   A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation [J].
Loktev, Alexander V. ;
Zhang, Qihong ;
Beck, John S. ;
Searby, Charles C. ;
Scheetz, Todd E. ;
Bazan, J. Fernando ;
Slusarski, Diane C. ;
Sheffield, Val C. ;
Jackson, Peter K. ;
Nachury, Maxence V. .
DEVELOPMENTAL CELL, 2008, 15 (06) :854-865
[47]   Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1 [J].
Lopes, Carla A. M. ;
Prosser, Suzanna L. ;
Romio, Leila ;
Hirst, Robert A. ;
O'Callaghan, Chris ;
Woolf, Adrian S. ;
Fry, Andrew M. .
JOURNAL OF CELL SCIENCE, 2011, 124 (04) :600-612
[48]   The C-elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus [J].
Malone, CJ ;
Misner, L ;
Le Bot, N ;
Tsai, MC ;
Campbell, JM ;
Ahringer, J ;
White, JG .
CELL, 2003, 115 (07) :825-836
[49]   Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling [J].
Mao, Yingwei ;
Ge, Xuecai ;
Frank, Christopher L. ;
Madison, Jon M. ;
Koehler, Angela N. ;
Doud, Mary Kathryn ;
Tassa, Carlos ;
Berry, Erin M. ;
Soda, Takahiro ;
Singh, Karun K. ;
Biechele, Travis ;
Petryshen, Tracey L. ;
Moon, Randall T. ;
Haggarty, Stephen J. ;
Tsai, Li-Huei .
CELL, 2009, 136 (06) :1017-1031
[50]   Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons [J].
McEwen, Dyke P. ;
Koenekoop, Robert K. ;
Khanna, Hemant ;
Jenkins, Paul M. ;
Lopez, Irma ;
Swaroop, Anand ;
Martens, Jeffrey R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (40) :15917-15922