Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

被引：64
作者：
Jessen, F
Block, W
Träber, F
Keller, E
Flacke, S
Lamerichs, R
Schild, HH
Heun, R
机构：
[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
[2] Univ Bonn, Dept Radiol, D-53105 Bonn, Germany
[3] Philips Med Syst, Best, Netherlands
来源：
NEUROLOGY | 2001年 / 57卷 / 05期
关键词：
D O I：
10.1212/WNL.57.5.930
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this H-1-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.
引用
收藏
页码：930 / 932
页数：3
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