Investigation of In Vitro Release of Cisplatin from Electrostatically Crosslinked Chitosan-Alginate Nanoparticles

被引：10

作者：

Maan, Gurvindar Kaur ^{[1
]}

Bajpai, Jaya ^{[1
]}

Bajpai, Anil K. ^{[1
]}

机构：

[1] Govt Autonomous Sci Coll, Dept Chem, Bose Mem Res Lab, Jabalpur 482003, MP, India

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2016年 / 46卷 / 10期

关键词：

chitosan/alginate; nanoparticles; cisplatin; drug delivery system; DRUG-DELIVERY SYSTEMS; BIOMATERIALS; HYDROGELS; GELATIN; COMPLEX; DESIGN; CANCER;

D O I：

10.1080/15533174.2015.1137012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The major aim of this study was to design chitosan/alginate nanoparticles as swelling controlled drug release system for anticancer drugs. The prepared nanoparticles were characterized by FTIR and transmission electron microscopy analysis and their biocompatibility and in vitro cytotoxicity were evaluated. The nanoparticles were loaded with widely used anticancer drug, cisplatin, and controlled release of drug was investigated to observe the effects of various parameters such as percent loading of the drug, pH, temperature, and nature of release media on the release profiles. The release of cisplatin was also studied in various simulated biological fluids.

引用

页码：1532 / 1540

页数：9

共 36 条

[1] EFFECT OF CHITOSAN ON THE PERMEABILITY OF MONOLAYERS OF INTESTINAL EPITHELIAL-CELLS (CACO-2) [J].

ARTURSSON, P ;

LINDMARK, T ;

DAVIS, SS ;

ILLUM, L .

PHARMACEUTICAL RESEARCH, 1994, 11 (09) :1358-1361

[2] Alginate hydrogels as biomaterials [J].

Augst, Alexander D. ;

Kong, Hyun Joon ;

Mooney, David J. .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (08) :623-633

[3] Preparation and characterization of macroporous poly(2-hydroxyethyl methacrylate)-based biomaterials:: Water sorption property and in vitro blood compatibility [J].

Bajpai, A. K. ;

Kankane, Sanjana .

JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 104 (03) :1559-1571

[4] Development of Poly(acrylamide)-Hydroxyapatite Composites as Bone Substitutes: Study of Mechanical and Blood Compatible Behavior [J].

Bajpai, A. K. ;

Bundela, H. .

POLYMER COMPOSITES, 2009, 30 (10) :1532-1543

[5] Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate [J].

Bajpai, AK ;

Choubey, J .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2006, 17 (04) :345-358

[6] Dynamic and equilibrium studies on adsorption of Cr(VI) ions onto binary bio-polymeric beads of cross linked alginate and gelatin [J].

Bajpai, J ;

Shrivastava, R ;

Bajpai, AK .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2004, 236 (1-3) :81-90

[7]

Barratt G., 2003, CELL MOL LIFE SCI, V21, P885

[8]

Bravo Osuna I., 2008, EUR J PHARM BIOPHARM, V69, P436

[9] Starch vermicelli template for synthesis of magnetic iron oxide nanoclusters [J].

Chairam, Sanoe ;

Somsook, Ekasith .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2008, 320 (15) :2039-2043

[10] A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery [J].

Chen, SC ;

Wu, YC ;

Mi, FL ;

Lin, YH ;

Yu, LC ;

Sung, HW .

JOURNAL OF CONTROLLED RELEASE, 2004, 96 (02) :285-300

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