N2,N2′-disubstituted oxalic acid bishydrazides: novel ligands for copper-catalyzed C-N coupling reactions in water

被引：15

作者：

Meng, Fei ^{[1
]}

Wang, Chenxia ^{[1
]}

Xie, Jianwei ^{[1
]}

Zhu, Xinhai ^{[1
]}

Wan, Yiqian ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2011年 / 25卷 / 05期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

amination; cross-coupling; copper; microwave chemistry; water chemistry; ARYL HALIDES; AMINO-ACIDS; ARYLATION; EFFICIENT; AMINATION; IODIDES;

D O I：

10.1002/aoc.1765

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of N-2,N-2'-disubstituted oxalic acid bishydrazideswere synthesized. Some, for example, N-2,N-2'-di-1-(4-methoxyphenyl)-ethanyloxylic-(bishydrazide), are novel and effective ligands for copper-catalyzed Ullmann-type C-N coupling reaction in water. A variety of amines could be effectively N-arylated with aryl halides under both microwave irradiation and conventional heating (even at 30 degrees C) with good to excellent yields. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：341 / 347

页数：7

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