Serum Endocan Levels Are Correlated with the Presence and Severity of Coronary Artery Disease in Patients with Hypertension

被引：62

作者：

Wang, Xiang-sheng ^{[1
]}

Yang, Wen ^{[3
]}

Luo, Tong ^{[1
]}

Wang, Jian-ming ^{[2
]}

Jing, Yan-yan ^{[4
]}

机构：

[1] Chinese Med Hosp Jining, Dept Internal Med, Jining, Peoples R China

[2] Chinese Med Hosp Jining, Dept Cardiovasc Med, Jining, Peoples R China

[3] Qingdao Univ, Affiliated Yuhuangding Hosp, Dept Nephrol, Yantai 264000, Peoples R China

[4] Qingdao Univ, Affiliated Yuhuangding Hosp, Dept Cardiol, Yantai 264000, Peoples R China

来源：

GENETIC TESTING AND MOLECULAR BIOMARKERS | 2015年 / 19卷 / 03期

关键词：

CELL-SPECIFIC MOLECULE-1; ENDOTHELIAL FUNCTION; PSORIASIS; THERAPY; MARKER; ESM-1;

D O I：

10.1089/gtmb.2014.0274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Endothelial dysfunction is one of the most important early indicators of atherosclerosis in hypertension (HT) patients. Endocan has been reported to play a role in the pathophysiology of endothelial dysfunction. Objective: We sought to assess whether serum endocan levels are correlated with the presence and severity of coronary artery disease (CAD) in patients with HT. Methods: We measured endocan levels in 164 patients with HT and in 55 controls. The severity of CAD was assessed by the coronary atherosclerosis index scores. Results: Serum endocan levels were independently correlated with the presence and severity of CAD in HT patients. Conclusion: Endocan might function as a useful biomarker for monitoring the development and progression of CAD in HT patients.

引用

页码：124 / 127

页数：4

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