Fetal environment, epigenetics, and pediatric renal disease

被引：36
|
作者：
Woroniecki, Robert [2 ]
Gaikwad, Anil Bhanudas [1 ]
Susztak, Katalin [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Med, Div Nephrol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA
来源：
PEDIATRIC NEPHROLOGY | 2011年 / 26卷 / 05期
关键词：
Epigenetics; Intrauterine environment; Histone modification; DNA methylation; LYSINE-4; METHYLTRANSFERASE; GLOMERULAR NUMBER; GENE-EXPRESSION; HISTONE; METHYLATION; HYPERTENSION; RELEVANCE; ANGELMAN; MECP2;
D O I：
10.1007/s00467-010-1714-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The notion that some adult diseases may have their origins in utero has recently captured scientists' attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.
引用
收藏
页码：705 / 711
页数：7
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