Fetal environment, epigenetics, and pediatric renal disease

被引：36
|
作者：
Woroniecki, Robert [2 ]
Gaikwad, Anil Bhanudas [1 ]
Susztak, Katalin [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Med, Div Nephrol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA
来源：
PEDIATRIC NEPHROLOGY | 2011年 / 26卷 / 05期
关键词：
Epigenetics; Intrauterine environment; Histone modification; DNA methylation; LYSINE-4; METHYLTRANSFERASE; GLOMERULAR NUMBER; GENE-EXPRESSION; HISTONE; METHYLATION; HYPERTENSION; RELEVANCE; ANGELMAN; MECP2;
D O I：
10.1007/s00467-010-1714-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The notion that some adult diseases may have their origins in utero has recently captured scientists' attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.
引用
收藏
页码：705 / 711
页数：7
相关论文
共 50 条
  • [21] The impact of epigenetics on cardiovascular disease
    Prasher, Dimple
    Greenway, Steven C.
    Singh, Raja B.
    BIOCHEMISTRY AND CELL BIOLOGY, 2020, 98 (01) : 12 - 22
  • [22] Epigenetics in Congenital Heart Disease
    Wang, Guanglei
    Wang, Bingbing
    Yang, Peixin
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2022, 11 (07):
  • [23] Epigenetics in inflammatory bowel disease
    Jenke, Andreas C.
    Zilbauer, Matthias
    CURRENT OPINION IN GASTROENTEROLOGY, 2012, 28 (06) : 577 - 584
  • [24] On the epigenetics of vascular regulation and disease
    Schleithoff, Christina
    Voelter-Mahlknecht, Susanne
    Dahmke, Indra Navina
    Mahlknecht, Ulrich
    CLINICAL EPIGENETICS, 2012, 4
  • [25] Epigenetics of Alzheimer's Disease
    Nikolac Perkovic, Matea
    Videtic Paska, Alja
    Konjevod, Marcela
    Kouter, Katarina
    Svob Strac, Dubravka
    Nedic Erjavec, Gordana
    Pivac, Nela
    BIOMOLECULES, 2021, 11 (02) : 1 - 40
  • [26] Epigenetics and Cardiovascular Disease in Diabetes
    Pasquier, Jennifer
    Hoarau-Vechot, Jessica
    Fakhro, Khalid
    Rafii, Arash
    Khalil, Charbel Abi
    CURRENT DIABETES REPORTS, 2015, 15 (12)
  • [27] Epigenetics in Alzheimer's Disease
    Gao, Xiaodie
    Chen, Qiang
    Yao, Hua
    Tan, Jie
    Liu, Zheng
    Zhou, Yan
    Zou, Zhenyou
    FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [28] Update on epigenetics in allergic disease
    Harb, Hani
    Renz, Harald
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 135 (01) : 15 - 24
  • [29] Advances in epigenetics link genetics to the environment and disease
    Cavalli, Giacomo
    Heard, Edith
    NATURE, 2019, 571 (7766) : 489 - 499
  • [30] Targeting epigenetics and lncRNAs in liver disease: From mechanisms to therapeutics
    Peng, Xiao-Fei
    Huang, Shi-Feng
    Chen, Ling-Juan
    Xu, Lingqing
    Ye, Wen-Chu
    PHARMACOLOGICAL RESEARCH, 2021, 172
12345