Th1/Th2 Cell Differentiation and Molecular Signals

被引：181

作者：

Zhang, Yuan ^{[1
]}

Zhang, Yaguang ^{[1
]}

Gu, Wangpeng ^{[1
]}

Sun, Bing ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China

来源：

T HELPER CELL DIFFERENTIATION AND THEIR FUNCTION | 2014年 / 841卷

关键词：

Th1/Th2; Transcription factor; Migration; Epigenetics; MicroRNA; LnRNA; LONG NONCODING RNAS; T-HELPER-CELLS; CHEMOKINE RECEPTOR EXPRESSION; PROTEIN-COUPLED RECEPTOR; TRANSCRIPTION-FACTOR; FUNCTIONAL EXPRESSION; CUTTING EDGE; LYMPHOCYTE EGRESS; INTERFERON-GAMMA; TH1; DEVELOPMENT;

D O I：

10.1007/978-94-017-9487-9_2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The distinctive differentiated states of the CD4+ T helper cells are determined by the set of transcription factors and the genes transcribed by the transcription factors. In vitro induction models, the major determinants of the cytokines present during the T-cell receptor (TCR)-mediated activation process. IL-12 and IFN-gamma make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make Naive CD4+ T cells highly express STAT6 and GATA3 and differentiated to TH2 cells. Even through T-bet and GATA3 are master regulators for TH1/TH2 cells differentiation. There are many other transcription factors, such as RUNX family proteins, IRF4, Dec2, Gfi1, Hlx, and JunB that can impair TH1/TH2 cells differentiation. In recent years, noncoding RNAs (microRNA and long non-coding RNA) join in the crowd. The leukocytes should migrate to the right place to show their impact. There are some successful strategies, which are revealed to targeting chemokines and their receptors, that have been developed to treat human immune-related diseases.

引用

页码：15 / 44

页数：30

共 189 条

[1] T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells [J].