Obesity and insulin resistance in women with polycystic ovary syndrome

被引：18

作者：

Hsu Chun-Sen ^{[1
]}

Wu Chien-Hua ^{[2
]}

Chiu Wan-Chun ^{[3
]}

Lee Ching-Tzu ^{[4
]}

Chang Chun-Jen ^{[5
]}

Hsu Ming-, I ^{[1
]}

机构：

[1] Taipei Med Univ, Dept Obstet & Gynecol, Wan Fang Hosp, Taipei 116, Taiwan

[2] Chung Yuan Christian Univ, Dept Appl Math, Chungli, Taiwan

[3] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 116, Taiwan

[4] Taipei Med Univ, Dept Tradit Med, Wan Fang Hosp, Taipei 116, Taiwan

[5] Taipei Med Univ, Dept Internal Med, Wan Fang Hosp, Sect Endocrinol & Metab, Taipei 116, Taiwan

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2011年 / 27卷 / 05期

关键词：

Polycystic ovary syndrome; phenotypes; obesity; insulin resistance; GLUCOSE CLAMP TECHNIQUE; DIAGNOSTIC-CRITERIA; ROTTERDAM CRITERIA; METABOLIC SYNDROME; CHINESE WOMEN; SENSITIVITY; PREVALENCE; TOLERANCE; WEIGHT; ADIPONECTIN;

D O I：

10.3109/09513590.2010.488776

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). Methods. ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. Results. The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7). Conclusion. The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.

引用

页码：300 / 306

页数：7

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