Diterpenes from Cryptomeria japonica inhibit androgen receptor transcriptional activity in prostate cancer cells

被引：19
|
作者：
Tu, Wei-Chun
Wang, Sheng-Yang
Chien, Shih-Chang
Lin, Feng-Min
Chen, Li-Ru
Chiu, Chih-Yang
Hsiao, Pei-Wen
机构：
[1] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan
[2] Natl Chung Hsing Univ, Dept Forestry, Taichung 40227, Taiwan
来源：
PLANTA MEDICA | 2007年 / 73卷 / 13期
关键词：
D O I：
10.1055/s-2007-990233
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one (2), sugiol (3), ferruginol (4), and 5-epixanthoperol (7) have near 100% AR inhibition efficacy at concentrations of 10, 5, 25, and 25 mu M, respectively. Because these compounds have very similar structures, analysis of their differential activity may aid in the design of inhibitors for PCa treatment.
引用
收藏
页码：1407 / 1409
页数：3
相关论文
共 50 条
  • [31] Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines
    Laschak, Martin
    Bechtel, Marina
    Spindler, Klaus-Dieter
    Hessenauer, Andrea
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2011, 28 (04) : 645 - 651
  • [32] Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer
    Dutta, Samikshan
    Polavaram, Navatha Shree
    Islam, Ridwan
    Bhattacharya, Sreyashi
    Bodas, Sanika
    Mayr, Thomas
    Roy, Sohini
    Albala, Sophie Alvarez Y.
    Toma, Marieta, I
    Darehshouri, Anza
    Borkowetz, Angelika
    Conrad, Stefanie
    Fuessel, Susanne
    Wirth, Manfred
    Baretton, Gustavo B.
    Hofbauer, Lorenz C.
    Ghosh, Paramita
    Pienta, Kenneth J.
    Klinkebiel, David L.
    Batra, Surinder K.
    Muders, Michael H.
    Datta, Kaustubh
    ONCOGENE, 2022, 41 (30) : 3747 - 3760
  • [33] Three new abietane-type diterpenes from the bark of Cryptomeria japonica
    Chang, Chi-I
    Chen, Chien-Chih
    Wang, Sheng-Yang
    Chang, Hsun-Shuo
    Chao, Louis Kuoping
    Chen, Jih-Jung
    Chen, Cheng-Chi
    Kuo, Yueh-Hsiung
    PHYTOCHEMISTRY LETTERS, 2017, 19 : 46 - 49
  • [34] Spatial profiling of androgen receptor splice variant 7 transcriptional activity in prostate cancer metastases
    Sprenger, Cynthia C.
    Coleman, Ilsa
    Kriner, Michelle
    Brady, Lauren
    Hoang, Margaret
    Roudier, Martine
    Damodarasamy, Mamatha
    Patel, Radhika
    True, Lawrence
    Nelson, Peter
    Haffner, Michael
    Plymate, Stephen
    CANCER RESEARCH, 2022, 82 (12)
  • [35] Niphatenones, Glycerol Ethers from the Sponge Niphates digitalis Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity
    Meimetis, Labros G.
    Williams, David E.
    Mawji, Nasrin R.
    Banuelos, Carmen A.
    Lal, Aaron A.
    Park, Jacob J.
    Tien, Amy H.
    Fernandez, Javier Garcia
    de Voogd, Nicole J.
    Sadar, Marianne D.
    Andersen, Raymond J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (01) : 503 - 514
  • [36] Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells
    Sun, You
    Jiang, Mingyue
    Park, Pil-Hoon
    Song, Kyung
    ARCHIVES OF PHARMACAL RESEARCH, 2020, 43 (04) : 433 - 448
  • [37] Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells
    You Sun
    Mingyue Jiang
    Pil-Hoon Park
    Kyung Song
    Archives of Pharmacal Research, 2020, 43 : 433 - 448
  • [38] Quantitative modeling of androgen receptor-mediated transcriptional complexes in human prostate cancer cells
    Hsiao, Jordy J.
    Martinez, Hairyl D.
    Wright, Michael E.
    CANCER RESEARCH, 2011, 71
  • [39] The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells
    Olokpa, Emuejevoke
    Bolden, Adrienne
    Stewart, Lamonica V.
    JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (12) : 2664 - 2672
  • [40] Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity
    Tararova, Natalia D.
    Narizhneva, Natalya
    Krivokrisenko, Vadirn
    Gudkov, Andrei V.
    Gurova, Katerina V.
    PROSTATE, 2007, 67 (16): : 1801 - 1815
12345