Diterpenes from Cryptomeria japonica inhibit androgen receptor transcriptional activity in prostate cancer cells

被引：19
|
作者：
Tu, Wei-Chun
Wang, Sheng-Yang
Chien, Shih-Chang
Lin, Feng-Min
Chen, Li-Ru
Chiu, Chih-Yang
Hsiao, Pei-Wen
机构：
[1] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan
[2] Natl Chung Hsing Univ, Dept Forestry, Taichung 40227, Taiwan
来源：
PLANTA MEDICA | 2007年 / 73卷 / 13期
关键词：
D O I：
10.1055/s-2007-990233
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one (2), sugiol (3), ferruginol (4), and 5-epixanthoperol (7) have near 100% AR inhibition efficacy at concentrations of 10, 5, 25, and 25 mu M, respectively. Because these compounds have very similar structures, analysis of their differential activity may aid in the design of inhibitors for PCa treatment.
引用
收藏
页码：1407 / 1409
页数：3
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