Infantile spasms: A U.S. consensus report

被引:355
作者
Pellock, John M. [1 ]
Hrachovy, Richard [2 ]
Shinnar, Shlomo [3 ]
Baram, Tallie Z. [4 ]
Bettis, David [5 ]
Dlugos, Dennis J. [6 ]
Gaillard, William D. [7 ]
Gibson, Patricia A. [8 ,9 ]
Holmes, Gregory L. [10 ]
Nordli, Douglas R. [11 ]
O'Dell, Christine [12 ]
Shields, W. Donald [13 ]
Trevathan, Edwin [14 ]
Wheless, James W. [15 ]
机构
[1] Virginia Commonwealth Univ, Dept Neurol, Div Child Neurol, Sch Med, Richmond, VA 23298 USA
[2] Baylor Coll Med, Dept Neurol, Peter Kellaway Sect Neurophysiol, Houston, TX 77030 USA
[3] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA
[4] Univ Calif Irvine, Sch Med, Dept Neurol, Irvine, CA 92717 USA
[5] Pediat Neurol Idaho, Boise, ID USA
[6] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[7] Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA
[8] Wake Forest Univ, Comprehens Epilepsy Program, Winston Salem, NC 27109 USA
[9] Wake Forest Univ, Epilepsy Informat Serv, Winston Salem, NC 27109 USA
[10] Dartmouth Hitchcock Med Ctr, Dept Neurol, Lebanon, NH 03766 USA
[11] Childrens Mem Hosp, Epilepsy Ctr, Chicago, IL 60614 USA
[12] Montefiore Med Ctr, Comprehens Epilepsy Management Ctr, Bronx, NY 10467 USA
[13] Univ Calif Los Angeles, Dept Neurol, Mattel Childrens Hosp, Los Angeles, CA 90024 USA
[14] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA
[15] Univ Tennessee, Hlth Sci Ctr, Dept Pediat Neurol, Memphis, TN USA
关键词
West syndrome; Encephalopathic epilepsy; Adrenocorticotropic hormone; Vigabatrin; Corticosteroids; Infantile spasms; Treatment; AUTISM SPECTRUM DISORDERS; TUBEROUS SCLEROSIS; KETOGENIC DIET; WEST-SYNDROME; ACTH THERAPY; DESCRIPTIVE EPIDEMIOLOGY; CORTICOTROPIN THERAPY; COMPARING VIGABATRIN; PEDIATRIC EPILEPSY; 1ST-LINE TREATMENT;
D O I
10.1111/j.1528-1167.2010.02657.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
P>The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician. Although an evidence-based practice guideline with full literature review was published in 2004, diversity in IS evaluation and treatment remains and highlights the need for further consensus to optimize outcomes in IS. For this purpose, a working group committed to the diagnosis, treatment, and establishment of a continuum of care for patients with IS and their families-the Infantile Spasms Working Group (ISWG)-was convened. The ISWG participated in a workshop for which the key objectives were to review the state of our understanding of IS, assess the scientific evidence regarding efficacy of currently available therapeutic options, and arrive at a consensus on protocols for diagnostic workup and management of IS that can serve as a guide to help specialists and general pediatricians optimally manage infants with IS. The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first-line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification. Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS.
引用
收藏
页码:2175 / 2189
页数:15
相关论文
共 110 条
[1]  
Appleton R, 2000, BRIT MED J, V320, P1404
[2]   Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms [J].
Appleton, RE ;
Peters, ACB ;
Mumford, JP ;
Shaw, DE .
EPILEPSIA, 1999, 40 (11) :1627-1633
[3]  
Aydmh N, 1998, PEDIATR NEUROL, V19, P211
[4]   Models for infantile spasms: An arduous journey to the holy grail... [J].
Baram, Tallie Z. .
ANNALS OF NEUROLOGY, 2007, 61 (02) :89-91
[5]  
Baram TZ, 1996, PEDIATRICS, V97, P375
[6]   CORTICOTROPIN-RELEASING HORMONE INDUCED SEIZURES IN INFANT RATS ORIGINATE IN THE AMYGDALA [J].
BARAM, TZ ;
HIRSCH, E ;
SNEAD, OC ;
SCHULTZ, L .
ANNALS OF NEUROLOGY, 1992, 31 (05) :488-494
[7]   PATHOPHYSIOLOGY OF MASSIVE INFANTILE SPASMS - PERSPECTIVE ON THE PUTATIVE ROLE OF THE BRAIN ADRENAL AXIS [J].
BARAM, TZ .
ANNALS OF NEUROLOGY, 1993, 33 (03) :231-236
[8]   BRAIN-ADRENAL AXIS HORMONES ARE ALTERED IN THE CSF OF INFANTS WITH MASSIVE INFANTILE SPASMS [J].
BARAM, TZ ;
MITCHELL, WG ;
SNEAD, OC ;
HORTON, EJ ;
SAITO, M .
NEUROLOGY, 1992, 42 (06) :1171-1175
[9]   ACTH DOES NOT CONTROL NEONATAL SEIZURES INDUCED BY ADMINISTRATION OF EXOGENOUS CORTICOTROPIN-RELEASING HORMONE [J].
BARAM, TZ ;
SCHULTZ, L .
EPILEPSIA, 1995, 36 (02) :174-178
[10]   Early control of seizures improves long-term outcome in children with tuberous sclerosis complex [J].
Bombardieri, Roberta ;
Pinci, Mariangela ;
Moavero, Romina ;
Cerminara, Caterina ;
Curatolo, Paolo .
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2010, 14 (02) :146-149