Effects of phencyclidine metabolites on serotonin uptake in rat brain

被引：16
作者：
Hori, T
Suzuki, T
Baba, A
Abe, S
Yamamoto, T
Moroji, T
Shiraishi, H
机构：
[1] YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI,LAB MOL RECOGNIT,YOKOHAMA,KANAGAWA,JAPAN
[2] SAPPORO HANAZONO HOSP,SAPPORO,HOKKAIDO,JAPAN
来源：
NEUROSCIENCE LETTERS | 1996年 / 209卷 / 03期
关键词：
phencyclidine (PCP); 4-phenyl-4-(1-piperidinyl)cyclohexanol (4-PPC); serotonin uptake; rat brain;
D O I：
10.1016/0304-3940(96)11617-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of phencyclidine (PCP) and its metabolites on serotonin (5-hydroxytryptamine, 5-HT) receptors were studied. PCP and its metabolites inhibited the uptake of [H-3]5-HT and the binding of [H-3]paroxetine in rat brain, while they failed to inhibit either [H-3]5-HT binding to 5-HT1 receptors or [3H]ketanserin binding to 5-HT2 receptors. The trans-isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol (trans-4-PPC), the major metabolite of PCP, rather than PCP itself, inhibited [H-3]5-HT uptake most potently. These results suggest that the serotonergic effects of PCP, in part, may be based on the effects of PCP metabolites on 5-HT uptake.
引用
收藏
页码：153 / 156
页数：4
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