Current and research therapies for the prevention and treatment of delayed neurological syndrome associated with carbon monoxide poisoning: A narrative review

被引：9

作者：

del Moral-Barbudo, B. ^{[1
]}

Blancas, R. ^{[1
,2
]}

Ballesteros-Ortega, D. ^{[1
,3
]}

Quintana-Diaz, M. ^{[1
,4
]}

Martinez-Gonzalez, O. ^{[1
,2
]}

机构：

[1] Alfonso X El Sabio Univ, Villanueva De La Canada, Spain

[2] Del Tajo Univ Hosp, Crit Care Dept, Ave Amazonas Cent S-N, Aranjuez 28300, Spain

[3] Puerta de Hierro Univ Hosp, Crit Care Dept, Boadilla Del Monte, Spain

[4] La Paz Univ Hosp, Crit Care Dept, Madrid, Spain

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2020年 / 39卷 / 06期

关键词：

Carbon monoxide poisoning; delayed neurologic syndrome; delayed neurologic sequelae; hyperbaric oxygen therapy; HYPERBARIC-OXYGEN; RICH SALINE; ERYTHROPOIETIN; ENCEPHALOPATHY; SEQUELAE; METHANE; HEMIN; RATS;

D O I：

10.1177/0960327120901572

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains controversial due to the lack of evidence regarding its efficacy. The aim of this review is to report therapies under investigation for preventing or improving DNS, some of them with promising results in humans.

引用

页码：765 / 772

页数：8

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