Metalloproteinases and vulnerable atherosclerotic plaques

被引：213

作者：

Newby, Andrew C. ^{[1
]}

机构：

[1] Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2007年 / 17卷 / 08期

关键词：

D O I：

10.1016/j.tcm.2007.09.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plaque rupture is the main cause of myocardial infarctions and strokes. Ruptured plaques have thin, highly inflamed, and collagen-poor fibrous caps that contain elevated levels of proteases, including metalloproteinases (MMPs), which might weaken plaque caps and promote rupture. On the other hand, MMPs facilitate migration and proliferation vascular smooth muscle cells, which should promote fibrous cap stability. Given the dual effects of MMPs, therapies should selectively target harmful MMPs or the processes that cause MMP activity to rise to destructive levels.

引用

页码：253 / 258

页数：6

共 49 条

[1] Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma - A potential mechanism of lesion stabilization [J].

Aikawa, M ;

Rabkin, E ;

Okada, Y ;

Voglic, SJ ;

Clinton, SK ;

Brinckerhoff, CE ;

Sukhova, GK ;

Libby, P .

CIRCULATION, 1998, 97 (24) :2433-2444

[2]

Aikawa M, 2001, CIRCULATION, V103, P276

[3] Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis [J].

Bar-Or, A ;

Nuttall, RK ;

Duddy, M ;

Alter, A ;

Kim, HJ ;

Ifergan, I ;

Pennington, CJ ;

Bourgoin, P ;

Edwards, DR ;

Yong, VW .

BRAIN, 2003, 126 :2738-2749

[4] HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages [J].

Bellosta, S ;

Via, D ;

Canavesi, M ;

Pfister, P ;

Fumagalli, R ;

Paoletti, R ;

Bernini, F .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (11) :1671-1678

[5] Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells [J].

Bond, M ;

Chase, AJ ;

Baker, AH ;

Newby, AC .

CARDIOVASCULAR RESEARCH, 2001, 50 (03) :556-565

[6] Role of nuclear factor-κB activation in metalloproteinase-1,-3, and-9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo [J].

Chase, AJ ;

Bond, M ;

Crook, MF ;

Newby, AC .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (05) :765-771

[7] Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells [J].

Cho, A ;

Graves, J ;

Reidy, MA .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (12) :2527-2532

[8] Quantitation and localization of matrix metalloproteinases and their inhibitors in human carotid endarterectomy tissues [J].

Choudhary, Salman ;

Higgins, Catherine L. ;

Chen, Iou Yih ;

Reardon, Michael ;

Lawrie, Gerald ;

Vick, G. Wesley, III ;

Karmonik, Christof ;

Via, David P. ;

Morrisett, Joel D. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (10) :2351-2358

[9] Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human [J].

Cipollone, F ;

Fazia, ML ;

Iezzi, A ;

Cuccurullo, C ;

De Cesare, D ;

Ucchino, S ;

Spigonardo, F ;

Marchetti, A ;

Buttitta, F ;

Paloscia, L ;

Mascellanti, M ;

Cuccurullo, F ;

Mezzetti, A .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (09) :1925-1931

[10] Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques - Implications for plaque stabilization [J].

Crisby, M ;

Nordin-Fredriksson, G ;

Shah, PK ;

Yano, J ;

Zhu, J ;

Nilsson, J .

CIRCULATION, 2001, 103 (07) :926-933

← 1 2 3 4 5 →