Basic Science of Articular Cartilage

被引：288
作者：
Carballo, Camila B. [1 ]
Nakagawa, Yusuke [1 ,2 ]
Sekiya, Ichiro [2 ]
Rodeo, Scott A. [1 ]
机构：
[1] Hosp Special Surg, Tissue Engn Repair & Regenerat Program, 535 East 70th St, New York, NY 10021 USA
[2] Tokyo Med & Dent Univ, Ctr Stem Cells & Regenerat Med, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan
来源：
CLINICS IN SPORTS MEDICINE | 2017年 / 36卷 / 03期
关键词：
Articular cartilage; Chondrocytes; ECM; Chondrogenesis; Cartilage injuries; MESENCHYMAL STEM-CELLS; SYNOVIAL-FLUID; MATRIX; KNEE; CHONDROCYTES; COLLAGEN; JOINT; INFLAMMATION; DEGRADATION; PROGRESSION;
D O I：
10.1016/j.csm.2017.02.001
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
The most challenging aspects in treating articular cartilage injury include identifying the cellular and molecular mechanism(s) that lead to matrix changes and the differentiation and dedifferentiation behavior of chondrocytes, and understanding how they affect the structural integrity of the articular cartilage and tissue remodeling. Several treatment strategies have been proposed. A better understanding of the signaling pathways and growth and transcription factors for genes responsible for chondrogenesis is an important component in the development of new therapies to prevent cartilage degeneration or promote repair to replicate the physiologic and functional properties of the original cartilage.
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页码：413 / +
页数：14
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