Prostaglandin D2 receptor antagonism: a novel therapeutic option for eosinophilic asthma?

被引:7
作者
Brusselle, Guy G. [1 ,2 ,3 ]
Provoost, Sharen [1 ]
Maes, Tania [1 ]
机构
[1] Ghent Univ Hosp, Dept Resp Med, B-9000 Ghent, Belgium
[2] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
[3] Erasmus MC, Dept Resp Med, Rotterdam, Netherlands
关键词
CRTH2; ANTAGONIST; INFLAMMATION;
D O I
10.1016/S2213-2600(16)30201-6
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:676 / 677
页数:2
相关论文
共 50 条
  • [1] Prostaglandin D2 receptor antagonists in early development as potential therapeutic options for asthma
    Santus, Pierachille
    Radovanovic, Dejan
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2016, 25 (09) : 1083 - 1092
  • [2] New treatments for asthma: From the pathogenic role of prostaglandin D2 to the therapeutic effects of fevipiprant
    Pelaia, Corrado
    Crimi, Claudia
    Vatrella, Alessandro
    Busceti, Maria Teresa
    Gaudio, Achille
    Garofalo, Eugenio
    Bruni, Andrea
    Terracciano, Rosa
    Pelaia, Girolamo
    PHARMACOLOGICAL RESEARCH, 2020, 155
  • [3] The impact of the prostaglandin D2 receptor 2 and its downstream effects on the pathophysiology of asthma
    Brightling, Christopher E.
    Brusselle, Guy
    Altman, Pablo
    ALLERGY, 2020, 75 (04) : 761 - 768
  • [4] The pharmacology of the prostaglandin D2 receptor 2 (DP2) receptor antagonist, fevipiprant
    Brightling, Chris
    Kulkarni, Swarupa
    Lambrecht, Bart N.
    Sandham, David
    Weiss, Markus
    Altman, Pablo
    PULMONARY PHARMACOLOGY & THERAPEUTICS, 2021, 68
  • [5] Discovery of orally active prostaglandin D2 receptor antagonists
    Torisu, K
    Kobayashi, K
    Iwahashi, M
    Nakai, Y
    Onoda, T
    Nagase, T
    Sugimoto, I
    Okada, Y
    Matsumoto, R
    Nanbu, F
    Ohuchida, S
    Nakai, H
    Toda, M
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (19) : 4891 - 4895
  • [6] Role of Prostaglandin D2 Receptor CRTH2 in Sustained Eosinophil Accumulation in the Airways of Mice with Chronic Asthma
    Kagawa, Shizuko
    Fukunaga, Koichi
    Oguma, Tsuyoshi
    Suzuki, Yusuke
    Shiomi, Tetsuya
    Sayama, Koichi
    Kimura, Tokuhiro
    Hirai, Hiroyuki
    Nagata, Kinya
    Nakamura, Masataka
    Asano, Koichiro
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, 155 : 6 - 11
  • [7] Design and synthesis of new prostaglandin D2 receptor antagonists
    Iwahashi, Maki
    Takahashi, Eiji
    Tanaka, Motoyuki
    Matsunaga, Yoko
    Okada, Yutaka
    Matsumoto, Ryoji
    Nambu, Fumio
    Nakai, Hisao
    Toda, Masaaki
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (18) : 5361 - 5371
  • [8] Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma
    Gress, Christina
    Fuchs, Maximilian
    Carstensen-Aureche, Saskia
    Mueller, Meike
    Hohlfeld, Jens M.
    PLOS ONE, 2024, 19 (07):
  • [9] Anti-inflammatory effects of the prostaglandin D2/prostaglandin DP1 receptor and lipocalin-type prostaglandin D2 synthase/prostaglandin D2 pathways in bacteria-induced bovine endometrial tissue
    Wu, Jindi
    Bai, Fan
    Mao, Wei
    Liu, Bo
    Yang, Xiaolin
    Zhang, Jing
    Li, Tingting
    Borjigin, Gerelt
    Cao, Jinshan
    VETERINARY RESEARCH, 2022, 53 (01) : 98
  • [10] Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus
    Zhang, S.
    Wu, X.
    Yu, S.
    DISEASES OF THE ESOPHAGUS, 2014, 27 (06) : 601 - 606