Supramolecular nanofibers of self-assembling peptides and DDP to inhibit cancer cell growth

被引：6

作者：

Zhang, Xiaoli ^{[1
,2
,3
]}

Li, Can ^{[1
,2
,3
]}

Wang, Youzhi ^{[1
,2
,3
]}

Ou, Caiwen ^{[4
]}

Ji, Shenglu ^{[1
,2
,3
]}

Chen, Minsheng ^{[4
]}

Yang, Zhimou ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, Minist Educ, Key Lab Bioact Mat, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

[2] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

[4] Southern Med Univ, Dept Cardiol, Zhujiang Hosp, Guangzhou 510280, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 62期

关键词：

DRUG-DELIVERY; HYDROGELS; RELEASE;

D O I：

10.1039/c6ra08357a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report in this paper a molecular hydrogel formed by adding cis-dichlorodiamineplatinum(II) (DDP) to a self-assembling taxol-peptide amphiphile. Our study provides a novel self-assembling nano-medicine and hydrogel to deliver two anti-cancer drugs simultaneously.

引用

页码：S6903 / S6906

页数：4

共 36 条

[1] Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles [J].

Altunbas, Aysegul ;

Lee, Seung J. ;

Rajasekaran, Sigrid A. ;

Schneider, Joel P. ;

Pochan, Darrin J. .

BIOMATERIALS, 2011, 32 (25) :5906-5914

[2]

[Anonymous], 2012, ANGEW CHEM-GER EDIT, DOI DOI 10.1002/ANGE.201108612

[3] Inclusion of Tetracycline Hydrochloride within Supramolecular Gels and Its Controlled Release to Bovine Serum Albumin [J].

Chen, Liqin ;

Wu, Junchen ;

Lihui Yuwen ;

Shu, Tianmin ;

Xu, Miao ;

Zhang, Mingming ;

Yi, Tao .

LANGMUIR, 2009, 25 (15) :8434-8438

[4] Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative [J].

Gao, Yuan ;

Kuang, Yi ;

Guo, Zu-Feng ;

Guo, Zhihong ;

Krauss, Isaac J. ;

Xu, Bing .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (38) :13576-13577

[5]

Ikeda M, 2014, NAT CHEM, V6, P511, DOI [10.1038/NCHEM.1937, 10.1038/nchem.1937]

[6] MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin [J].

Kalafatovic, Daniela ;

Nobis, Max ;

Javid, Nadeem ;

Frederix, Pim W. J. M. ;

Anderson, Kurt I. ;

Saunders, Brian R. ;

Ulijn, Rein V. .

BIOMATERIALS SCIENCE, 2015, 3 (02) :246-249

[7] The resurgence of platinum-based cancer chemotherapy [J].

Kelland, Lloyd .

NATURE REVIEWS CANCER, 2007, 7 (08) :573-584

[8] Heavy metal ion hydrogelation of a self-assembling peptide via cysteinyl chelation [J].

Knerr, Patrick J. ;

Branco, Monica C. ;

Nagarkar, Radhika ;

Pochan, Darrin J. ;

Schneider, Joel P. .

JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (04) :1352-1357

[9]

Li J., 2015, ANGEW CHEM INT EDIT, V127, P13505

[10] Dephosphorylation of D-Peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy [J].

Li, Jiayang ;

Gao, Yuan ;

Kuang, Yi ;

Shi, Junfeng ;

Du, Xuewen ;

Zhou, Jie ;

Wang, Huaimin ;

Yang, Zhimou ;

Xu, Bing .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (26) :9907-9914

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